海洛因成瘾者复吸相关低频振幅特征的静息态fMRI研究

目的探讨海洛因成瘾者复吸相关的静息态脑功能特征。材料与方法 31例海洛因成瘾者参加本前瞻性纵向静息态功能磁共振研究,随访6个月后确定复吸组与非复吸组,分析两组大脑低频振幅差异,且分析差异区低频振幅值与复吸行为的相关性。结果与非复吸组相比,复吸组低频振幅值升高的脑区为右侧前扣带回、眶额回及颞中回,降低的脑区为左侧海马旁回、右侧后扣带回、双侧梭状回及左侧顶下小叶。结论海洛因成瘾复吸者与非复吸者大脑神经活动存在明显差异,控制功能的下降及学习记忆功能的异常增加与复吸行为密切相关,这些异常功能特征对海洛因成瘾者复吸风险具有一定的预测价值。

Abnormal amplitude of low-frequency fluctuation associated with relapse behavior in heroin addict: a resting-state functional magnetic resonance image study

Objective:To investigate the characteristics of the relapse related brain function of heroin addicts during the resting state.Materials and Methods:Thirty-one heroin addicts were included in a prospective longitudinal study of resting state functional magnetic resonance imaging.The relapse group and non relapse group were determined after six month-follow-up,and the differences in amplitude of low-frequency fluctuation (ALFF) value between two groups were analyzed.Then the relationship between ALFF value of differential regions and relapse behavior was analyzed.Results:Compared with non relapse group,the relapse group demonstrated significantly greater ALFF value in the right anterior cingulate gyrus,orbitoffontal gyrus and temporal gyrus,demonstrated lower ALFF value in the left parahippocampal gyrus,right posterior cingulate gyrus,bilateral fusiform gyrus and left inferior parietal lobule.No significantly relationship between the ALFF value of differential brain regions and relapse behavior was found.Conclusions:The relapses and non-relapses vary significantly in the brain function,the decline of control function and the abnormal increase of learuing and memory function are closely related with relapse behavior.These abnormal functional characteristics have a certain predictive value for the relapse risk of heroin addicts.