磁共振成像技术在肝脏铁过载的应用进展

原发性血色素沉着症、慢性肝病及血液病等均可导致铁过载,严重铁过载会导致肝脏、心脏、胰腺、甲状腺和中枢神经系统等器官功能障碍,甚至可致死亡。铁过载较先累及肝脏,磁共振成像(magnetic resonance imaging,MRI)能准确无创评估肝脏铁过载严重程度,且肝脏铁含量与人体总铁量具有高度相关,因此肝脏MRI铁定量技术对临床意义重大。本文主要对MRI技术在肝脏铁过载的应用进展作一综述。

MRI evaluation of hepatic iron overload: recent advances

Iron overload can be caused by hereditary hemochromatosis, hematological diseases, chronic liver disease and so on. Severe iron overload can result in liver, heart, pancreas, thyroid organs, the central nervous system, and other organ dysfunction, or even can cause death. Iron overload can result in liver damage firstly, and the liver iron concentration bring into correspondence with the body iron content. MRI can accurately noninvasive assess and monitor the liver iron concentration, provide guidance for clinical treatment. This article mainly introduces MRI-based methods for quantification of liver iron, including remaining challenges, unsolved problems and potential application prospect.