磁共振准连续动脉自旋标记技术在不随意运动型脑瘫患者中的初步研究

目的应用磁共振准连续动脉自旋标记(pseudo-continuous arterial spin labeling,pCASL)技术观察不随意运动型脑瘫患者脑部运动区(内囊后肢皮质脊髓束)的血流特点,通过血流变化来研究脑瘫患儿运动区的功能病理基础,为临床治疗效果及早期诊断提供影像支持。材料与方法回顾性分析经临床诊断为不随意运动型脑瘫患者与志愿者各20例,观察不随意运动型脑瘫患者双侧内囊后肢皮质脊髓束运动区脑血流量的变化,通过t检验分析志愿者、患儿及志愿者与患儿双侧脑血流的的情况。结果志愿者、不随意运动型脑瘫患者左、右两侧内囊后肢的皮质脊髓束运动区局部脑血流量差异有统计学意义(P0.05),左侧脑血流量高于右侧。志愿者与脑瘫患者左、右两侧局部脑血流量比较差异有统计学意义(P0.05),志愿者局部脑血流量高于不随意运动型脑瘫患者。结论双侧内囊后肢功能运动区脑血流减低是导致不随意运动型脑瘫运动区的功能病理基础之一,可以通过磁共振pCASL技术对不随意运动型脑瘫运动区的血流量进行定量分析。

The preliminary study of magnetic resonance pCASL technique in dyskinetic cerebral palsy patients

Objective: To observe the blood flow characteristics of brain movement area (posterior capsule cortex spinal cord bundle) in patients with involuntary movement of cerebral palsy by magnetic resonance pseudo-continuous arterial spin labeling (pCASL). To study the functional and pathological basis of the motor area of children with cerebral palsy by blood flow changes, and to provide the image support for clinical treatment and early diagnosis. Materials and Methods: Retrospective analysis of the clinical diagnosis of dyskinetic cerebral palsy patients and normal volunteers 20 cases, respectively, observed the change of dyskinetic cerebral palsy patients with bilateral posterior corticospinal motor area of cerebral blood flow, cerebral blood flow analysis of local motion area. t test was used to analyze the cerebral blood flow of bilateral cerebral blood flow in volunteers, children, volunteers and children. Results: There were significant differences in local cerebral blood flow and corticospinal motor area volunteers dyskinetic cerebral palsy patients with left and right sides of the posterior limb of the internal capsule (P<0.05), left cerebral blood flow was higher than right. There was significant differences in cerebral blood flow between the left and right side of the patients with cerebral palsy (P<0.05). Conclusions: The function of motor area of cerebral blood flow to reduce the bilateral posterior limb of the internal capsule which is one of the basic functions of pathological dyskinetic cerebral palsy movement area, can make quantitative analysis on the blood flow through magnetic resonance pCASL technique of dyskinetic cerebral palsy movement area analysis.