帕金森病伴快动眼睡眠行为障碍神经功能影像研究进展

帕金森病(Parkinson's disease,PD)是常见的神经系统变性疾病,以运动症状为主要表现,但同时合并许多非运动症状。研究发现约30%~60%的PD患者合并快动眼睡眠行为障碍(REM sleep behavior disorder,RBD),RBD不仅影响PD患者的睡眠品质,同时还易造成其自身及床伴受伤,增加认知受损的风险。但PD合并RBD(PDR)的机制却不清楚。随着影像学技术的发展,越来越多的研究正在寻求建立神经影像学标志物来检测PDR中大脑的变化,有望为该病早期诊断、疾病监测及明确发病机制提供重要线索。

An update of functional neuroimaging of REM sleep behavior disorder in Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disease. The main clinical manfiestation of PD are motor symptoms, but it is also related to non-motor symptoms. Studies found that RBD affects 30%—60% of patients with PD, it also easy to injure co-sleepers and increased cognitive impairment risk. However, the mechanism of PD and RBD (PDR) is unclear. With the advance of imaging technology, more and more studies seek to set up neuroimaging markers to explore brain alterations in patients with PDR. These studies will be helpful to the early diagnosis, monitoring disease progression and pathomechanism of PDR.