Sudanophilic lipid accumulation in astrocytes in periventricular leukomalacia in monkeys |
| |
| Authors: | S Mark Sumi |
| |
| Institution: | (1) Laboratory of Neuropathology, Department of Pathology, University of Washington School of Medicine, 98195 Seattle, WA, USA;(2) Child Development and Mental Retardation Center, RJ-05, University of Washington School of Medicine, 98195 Seattle, WA, USA |
| |
| Abstract: | Summary Sudanophilic lipid accumulation is a characteristic feature of periventricular leukomalacia (PVL) of infants. At least two types of lipid-containing cells have been identified, one being the macrophage, the other the  pre-myelin glial cell . A third type of lipid-containing cell has been seen in two monkeys with spontaneous PVL. Electron microscopically this cell appears to be an astrocyte. This probably represents a reaction of the astrocyte to hypoxia and may be the equivalent of the hypertrophic astrocytes found in human infants.Supported in part by NIH grant HDO 8633 and the Regional Primate Research Center Grant RR-00166 |
| |
| Keywords: | Astrocytes Sudanophilic lipids Periventricular leukomalacia |
| 本文献已被 SpringerLink 等数据库收录！ |
|
