| 短期重复暴露邻苯二甲酸二(2-乙基)己酯对雄性大鼠睾丸脂质过氧化水平的影响 |
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| 引用本文： | 逯晓波,刘秋芳,靳翠红,杜文聪,闫春晓.短期重复暴露邻苯二甲酸二(2-乙基)己酯对雄性大鼠睾丸脂质过氧化水平的影响[J].环境与健康杂志,2009,26(2). |
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| 作者姓名： | 逯晓波 刘秋芳 靳翠红 杜文聪 闫春晓 |
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| 作者单位： | 中国医科大学公共卫生学院卫生毒理教研室,辽宁,沈阳,110001 |
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| 摘 要： | 目的探讨邻苯二甲酸二(2-乙基)己酯(DEHP)短期重复暴露对雄性大鼠生殖毒性及睾丸脂质过氧化水平的影响。方法将初断乳清洁级Wistar雄性大鼠40只按体重随机分为DEHP低、中、高剂量组DEHP的染毒剂量分别为10、100、1 000 mg/(kg.d)]和溶剂对照组(玉米油),每组10只。采用灌胃方式进行染毒,连续染毒30 d。测定睾丸组织中丙二醛(MDA)和还原型谷胱甘肽(GSH)含量、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活力,蛋白定量采用酚试剂法。结果染毒第4周,DEHP高剂量染毒组体重、睾丸质量及其脏器系数低于溶剂对照组,差异均有统计学意义(P<0.05或P<0.01)。DEHP中、高剂量染毒组睾丸组织中MDA含量高于溶剂对照组,差异均有统计学意义(P<0.05),且MDA含量随着DEHP染毒剂量的增加而升高。DEHP高剂量染毒组睾丸组织中GSH含量、SOD和GSH-Px活力低于溶剂对照组,差异有统计学意义(P<0.05),且SOD和GSH-Px活力均随着DEHP染毒剂量的增加而降低。结论DEHP短期重复暴露对初断乳大鼠的生殖系统发育具有明显的毒性作用。DEHP及其代谢产...
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| 关 键 词： | 邻苯二甲酸二（2-乙基）己酯 脂质过氧化作用 生殖毒性 |
Study on Didymus Lipid Peroxidation Level on Rats after Sub-Acute Exposure to Di-2-ethylhexyl Phthalate |
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| LU Xiao-bo,LIU Qiu-fang,JIN Cui-hong,et al..Study on Didymus Lipid Peroxidation Level on Rats after Sub-Acute Exposure to Di-2-ethylhexyl Phthalate[J].Journal of Environment and Health,2009,26(2). |
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| Authors: | LU Xiao-bo LIU Qiu-fang JIN Cui-hong |
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| Institution: | LU Xiao-bo,LIU Qiu-fang,JIN Cui-hong,et al. Hygiene Toxicology Department,Public Health School,China Medical University,Shenyang,Liaoning 110001,China |
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| Abstract: | Objective To study genital toxicity and didymus lipid peroxidation level on rats after sub-acute exposure to di-2-ethylhexyl phthalate(DEHP).Methods The weaning Wistar andro-rats were dividied into four group randomly,and there were 10 rats in each group.Compared with the corn oil control,the experiment groups were gavaged consecutively for 30 days with the DEHP dose of 10,100,1 000 mg/(kg.d),The change of body weight was observed dynamically.All rats were executed by decapitation four weeks later and the d... |
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| Keywords: | Di-2-ethylhexyl phthalate Lipid peroxidation Genitaltoxicity |
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