| 热化疗对人体结肠癌LoVo细胞中一氧化氮含量的影响 |
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| 引用本文： | 卜淑芳,侯宝华,卿三华. 热化疗对人体结肠癌LoVo细胞中一氧化氮含量的影响[J]. 郑州大学学报(医学版), 2000, 35(1): 57-58 |
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| 作者姓名： | 卜淑芳 侯宝华 卿三华 |
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| 作者单位： | 郑州市中心医院内科!郑州4500072(卜淑芳)，第一军医大学南方医院普外科!广州510515(侯宝华，卿三华) |
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| 摘 要： | Aim To studythe effect of nitric oxide (NO) on LoVo cells after hyperthermia combined with MMC andtheir mechanisms. Methods The levels of NO were determined in cell culture medium of LoVocells by Cu-Cd reduction method.Results The levels of NO in control (45.9±16.12) μmol/Lgroup were lower than those in chemohyperthermy(92.3±24.30) μmol/L and hyperthermia(67.67±15.48)μmol/L group (P＜0.01，P＜0.05 respectively). Levels of NO inchemohyperthermy and hyperthermia groups were higher than those in chemotherapy(47.03±16.32)μmol/L(P＜0.01，P＜0.05respcevtively). The levels of NO in chemo-hyperthermy group were higher than those inhyperthermia group(P＜0.05)， and those in chemotherapy group higher than in controlgroup but without statistical significance.Conclusion Chemohyperthermy and hyperthermiacould remarkably enhance the levels of NO produced by LoVo cells. NO levels could also beenhanced by chemotherapy. It could be concluded that Nitric Oxide Synthase (NOS) in tumorcells might be activated by hyperthermia, chemohyperthermy and chemotherapy, and increasedNO level which induced cytotoxic reaction. This may be one of the mechanisms of treatmentwith chemohyperthermy.
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| 关 键 词： | 一氧化氮 LoVo细胞 热化疗 |
Effect of nitric oxide on LoVo cells after hyperthermia combined with MMC |
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| BU Shufang ),HOU Baohua ),QING Sanhua ) ). Effect of nitric oxide on LoVo cells after hyperthermia combined with MMC[J]. Journal of Zhengzhou University: Med Sci, 2000, 35(1): 57-58 |
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| Authors: | BU Shufang ) HOU Baohua ) QING Sanhua ) ) |
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| Affiliation: | BU Shufang 1),HOU Baohua 2),QING Sanhua 2) 1)Department of Internal Medicine,Zhengzhou Central Hospital,Zhengzhou 450007 2)Department of General Surgery,Nanfang Hospital,the First Military Medical University,Guangzhou 510515 |
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| Abstract: | |
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| Keywords: | nitric oxide LoVo cell chemohyperthermy |
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