胃癌中血管内皮生长因子的表达及其意义

目的探讨胃癌组织中血管内皮生长因子（Vascular endothelial growth factor，VEGF）的表达及其与临床病理学之间的关系。方法应用免疫组织化学方法检测55例胃癌组织、12例癌旁胃组织和正常胃组织中的VEGF蛋白的表达及微血管密度（MVD）。结果胃癌组织的VEGF阳性表达率为78．2％，主要集中于肿瘤细胞胞质内；胃癌组织中微血管分布不均，血管密集区主要集中在癌灶边缘。VEGF蛋白表达及MVD在胃癌组织中均显著高于癌旁胃组织及正常胃组织（P〈0．05）；胃癌中VEGF表达与浸润深度、淋巴结转移、病理分期、肿瘤分化程度密切相关（P〈0．05），而与患者的性别、年龄、肿瘤直径无关（P〉0．05）。结论VEGF在胃癌的发生、发展中起重要作用，有望作为胃癌抗血管治疗的靶标。

A Preliminary Study on the Expression and Significance of VEGF in Gastric Carcinoma

Objective To explore the role and the significance of Vascular endothelial growth factor （VEGF） expression and its relationship with clinieopathologic characteristics of gastric carcinoma（ GC ）. Methods Immunohistochemical staining was used to quantify VEGF expression and mierovessel density（MVD） in 55 cases of gastric cancer（GC） ,12 cases of adjacent normal tissue and normal gastric tissue. Results The expression rate of VEGF in GC was 78.2% , VEGF was mainly detected in cytoplasm of GC, the vascularity of GC tissue was asymmetry and mainly gathered on the edge of tumor. The expression of VEGF and MVD were significantly higher in GC than in adjacent normal tissues and normal gastric tissues （ P 〈 0.05 ）. In respect of infiltration depth,lymph node metastasis ,TNM stages and tumor＇s differentiation degrees （P 〈 0.05 ） were correlated with VEGF expression, but there was no significant correlation between the VEGF positive expression and patients＇ sex, age and tumor size （P 〉0. 05 ）. Conclusion VEGF may play an important role in the carcinogenesis and progression of GC and it hope to be a target for the therapy of anti-angiogenesis in GC.