In vitro cytotoxicity studies in bladder and renal cell cancer. |
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Authors: | M M Elhilali S K Nayak |
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Affiliation: | Urology Department, Sherbrooke University, Sherbrooke, Quebec, Canada |
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Abstract: | Attempts to obtain cell lines from bladder and renal cancer patients were done in 42 patients, with success to obtain primary cultures in 25 and long-term cultures in 7. Cell-mediated and humoral immunity was demonstrated in both tumors by microcytotoxicity in vitro. No cytotoxicity could be deomonstrated against target cells obtained from metastatic cancer tissue. Abrogation of cell-mediated immunity by serum factors was demonstrated. No recurrence was obtained in the group of patients showing positive lymphocytotoxicity during follow-up. |
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