| 食管鳞癌组织中p34^cdc2的表达变化及意义 |
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| 引用本文： | 华丛书,于在诚,刘芝华,骆爱萍. 食管鳞癌组织中p34^cdc2的表达变化及意义[J]. 山东医药, 2009, 49(38): 4-6 |
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| 作者姓名： | 华丛书 于在诚 刘芝华 骆爱萍 |
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| 作者单位： | 1. 安徽医科大学第一附属医院,合肥,234000
2. 中国医学科学院肿瘤研究所 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的观察人食管鳞癌组织中细胞分裂周期蛋白p34^cdc2的表达,并探讨其临床意义。方法利用组织芯片技术结合免疫组化及蛋白免疫印迹法检测138例食管癌患者肿瘤组织和配对正常食管黏膜组织中的p34^cdc2蛋白。结果p34^cdc2在食管鳞癌组织的表达明显高于配对正常黏膜组织,P〈0.01。p34^cdc2表达与食管鳞癌临床分期、淋巴结转移有关（P均〈0.05）,与分化程度和肿瘤浸润深度等无关（P均〉0.05）。结论食管癌组织中p34^cdc2表达升高。p34^cdc2可促进食管癌的发生与发展。
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| 关 键 词： | 食管肿瘤 食管鳞癌 p34cdc2蛋白 |
Expression and significane of p34cdc2 in esophageal squamous cell carcinoma |
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| HUA Cong-shu,YU Zai-cheng,LIU Zhi-hua,LUO Ai-ping. Expression and significane of p34cdc2 in esophageal squamous cell carcinoma[J]. Shandong Medical Journal, 2009, 49(38): 4-6 |
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| Authors: | HUA Cong-shu YU Zai-cheng LIU Zhi-hua LUO Ai-ping |
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| Affiliation: | HUA Cong-shu , YU Zai-cheng ,LIU Zhi-hua ,LUO Ai-ping (1 First Affiliated Hospital ,Anhui Medical University ,Hefei234000 , P. R. China) |
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| Abstract: | Objective To investigate the expression and significance of p34^cdc2 in human esophageal squamous cell carcinoma（ESSCC）. Methods The expression of p34^cdc2 in human esophageal cancer tissues（ n = 138） and corresponding normal mucosa were determined by tissue microarray（TMA） , immunohistochemical（IHC） method and Western blot analysis. Results The difference was statistically significant between the expression of p34^cdc2 in cancer tissues and their corresponding normal mucosas （P 〈 0.01 ）. Expression of p34^cdc2 was statistically relative with clinical stages and lymphatic metastasis （ P 〈 0.05 ）, but not relative with histological grades, depth of invasion （ P 〉 0.05 ）. Conclusion p34^cdc2 over express in ESSCC. It may promote the occurrence and development of ESSCC. |
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| Keywords: | esophageal neoplasm esophageal squamous cell carcinoma p34^cdc2 protein |
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