石菖蒲、川芎挥发油提取及包合工艺优选

目的优选通脑精胶囊中石菖蒲、川芎挥发油的最佳提取工艺和β-环糊精（-βcyclodextrin,-βCD）最佳包合工艺。方法以收油率为指标,采用单因素试验优选最佳提取工艺;以包合物收得率和挥发油包合率为指标,采用正交试验优选最佳包合工艺。结果挥发油的最佳提取工艺为：加10倍量水,提取11 h;最佳包合工艺为：挥发油与-βCD包合比为1 ml∶10 g,在50℃搅拌0.5 h进行包合。结论所优选提取工艺收油率较高,包合工艺稳定可行,适用于大生产。

Optimization of Extraction and Inclusion Technology of Volatile Oil in Acorus Tatarinowii Schott and Rhizoma Chuanxiong

Objective To optimize the extraction technology for volatile oil in Acorus Tatarinowii Schott and Rhizoma Chuanxiong and the inclusion technology for β-cyclodextrin(β-CD) in Tongnaojing Capsules.Methods The extraction conditions were evaluated by the ultimate oil extracting ratio with single-factor analysis,and the inclusion technology were optimized by the inclusion output ratio and oil-bearing ratio in the inclusion with orthogonal experiment.Results The optimum conditions for extraction were as follows:adding 10 times of the water,extracting materia medica for 11 hours.The best conditions for inclusion were as follows:the ratio of oil and β-CD being 1 ml∶10 g,and stirring for 0.5 hours at 50℃.Conclusion The extraction and inclusion conditions are optimal with high oi1 extract rate,the inclusion conditions are workable and can be used in industrial production.