Reversible changes in rat spermatogenesis induced by an antifertility substance (Gossypol). A histochemical report |
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| Authors: | S G Haider D Passia K Q Chen W E Stumpf |
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| Institution: | 1. Zentrum für Anatomie und Hirnforschung, Abteilung für Morphologische Endokrinologie und Histochemie der Universität Diisseldorf, FRG;2. Department of Anatomy, School of Medicine, University of North Carolina at Chapel Hill, USA |
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| Abstract: | Male rats received Gossypol 30 mg/kg body mass daily through intubation for 30 and 60 d. The testes were processed for histological and histochemical lipid staining, thiamine pyrophosphatase (TPPase), and alpha-glycerophosphate dehydrogenase (alpha-GPDH)--examinations. Gossypol induced effects were: various types of deformations of elongated spermatids, and their loss of orientation towards the lamina propria during the maturation phase; displacement of germ cells and occasionally also of Sertoli cells towards the lumen of the seminiferous tubule in form of a "puff". TPPase was observed in the supranuclear region of dislocated round spermatids and pachytene spermatocytes. alpha-GPDH was observed in the split pieces of mid- and tail pieces of elongated spermatids enclosed in the "puff". The induced effects were reversible. |
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