Determination of amprolium in feed by a liquid chromatography-mass spectrometry method |
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Authors: | Squadrone S Mauro C Ferro G L Amato G Abete M C |
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Affiliation: | aC.Re.A.A. – National Reference Center for the Surveillance and Monitoring of Animal feed, c/o Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e valle D’Aosta, Via Bologna 148, 10154 Torino, Italy |
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Abstract: | As a consequence of the finding of veterinarian drugs in food European Community banned several compounds like coccidiostats as amprolium (APL). This antibiotic has been used as a preventive and clinical anticoccidial drug in chicken. The 2005/187/CE, 2005/925/EC Recommendations ban the use of amprolium as additive in chicken feed. For this reason a rapid and sensitive liquid chromatography–mass spectrometry (LC–MS) method was developed to detect amprolium in chicken feed following the European community proposed technique (1999/27/EC) for sample preparation. Cause the validation is required for the analytical methods used in feed official control, this method was validated according to 2004/882/EC Regulation. |
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Keywords: | Validation Amprolium 2004/882/CE Regulation LC– MS |
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