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| 草分枝杆菌对难治性结核性脑膜炎患者外周血T淋巴细胞亚群的影响 | |
| 引用本文： | 马爱蕊,杨圣俊,王俊霞,闫纪英,周晓映,李洁,李新霞.草分枝杆菌对难治性结核性脑膜炎患者外周血T淋巴细胞亚群的影响[J].中国药业,2009,18(2):24-25. |
| 作者姓名： | 马爱蕊 杨圣俊 王俊霞 闫纪英 周晓映 李洁 李新霞 |
| 作者单位： | 1. 河北省胸科医院内科,河北,石家庄,050041 2. 河北省省医院保健科,河北,石家庄,050000 3. 河北省省直干休一所医务室,河北,石家庄,050051 |
| 摘 要： | 目的探讨草分枝杆菌对难治性结核性脑膜炎患者外周血中T淋巴细胞亚群的影响。方法选取2005年4月至2007年9月住院的未经抗结核治疗的难治性结核性脑膜炎患者84例，随机均分为两组。治疗组采用草分枝杆菌＋HRZE＋氟美松＋鞘内注药方案．对照组仅用HRZE＋氟关松＋鞘内注药方案治疗，用药4周。结果治疗组临床疗效明显优于对照组；与治疗组比较，CD3^＋及CD4^＋细胞明显增加．CD8^＋细胞降低，CD4^＋／CD8^＋值显著升高（P〈0．01）。结论草分枝杆菌对难治性结脑患者具有细胞免疫调节作用，疗效肯定，副作用小．是理想的抗结核辅助用药。 |
| 关 键 词： | 草分枝杆菌 难治性结核性脑膜炎 T淋巴细胞亚群 辅助治疗 |
Effect of Utilins on Peripheral T-Lymphocyte Subsets in Refractory Tuberculous Meningitis |
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| Ma Airui,Yang Shengjun,Wang Junxia,Yan Jiying,Zhou Xiaoying,Li Jie,Li Xinxia.Effect of Utilins on Peripheral T-Lymphocyte Subsets in Refractory Tuberculous Meningitis[J].China Pharmaceuticals,2009,18(2):24-25. | |
| Authors: | Ma Airui Yang Shengjun Wang Junxia Yan Jiying Zhou Xiaoying Li Jie Li Xinxia |
| Institution: | 1. Departmnt of Internal Medicinc, Hebei Provincial Thoracic Hospital, Shijiazhuang, Hebei, China 050041 2. Department of Health, Hebei Provincial Hospital, Shijiazhuang, Hebei, Chino 050000; 3. Medical Clinic, Hebei First Provincial Cadre＇s Sanatorium, Shijiazhuang, Hebei, China 050051) |
| Abstract: | Objective To investigate the effect of utilins on peripheral T-lymphocyte subsets in refractory tuberculous meningitis. Methods 84 inpatients of refractory tuberculous meningitis without antituberculosis treatment in April 2005 to September 2007, 25 females and 59 males, aged 15-78 years, were selected and randomly divided into two groups. The treatment group was given utilins ＋ HRZE ＋ dexam- ethasone ＋ intrathecal injection program, the control group was only given HRZE ＋ dexamethasone ＋ intratheeal injection program. The ther- apeutic courses all were 4 weeks. Results The effect in the treatment group was better than that in the control group. Compared with the treatment group, CD3^＋ and CD4^＋ markedly increased and CD8^＋ decreased, the value of CD4^＋/CD8^＋ obviously increased（P 〈 0. 01）. Conclusion Utllins treating refractory tuberculous meningitis has a role in cellular immune regulation with certain curative effect and less side effects. It is an ideal adjuvant anti- TB drug. |
| Keywords: | utilins refractory tuberculosis meningitis T- lymphocyte subsets adjuvant therapy |
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