Psychiatric comorbidity associated with co-occurring autism spectrum disorder and substance use disorder |
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| Affiliation: | 1. Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, United States;2. Vanderbilt University, Department of Psychology and Human Development, Nashville, TN, United States;3. Department of Psychiatry, Harvard Medical School, Boston, MA, United States;4. Lurie Center for Autism, Massachusetts General Hospital & Harvard Medical School, Lexington, MA, United States;1. Department of Psychological Sciences, Qatar University, Doha, Qatar;2. Department of Educational Psychology, The Hashemite University, Zarqa, Jordan;3. Child and Adolescent Health Service Development and Health Promotion, Primary Health Care Corporation, Doha, Qatar;1. School of Psychology, Cardiff University, Cardiff CF10 3AT, UK;2. Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King''s College London, London, UK;2. Hospital of Telemark, Kragerø, Norway;1. McGovern Medical School at UTHealth Houston, 6431 Fannin St, Houston, TX 77030, USA;2. George Washington University School of Medicine & Health Sciences, 2300 I St NW, Washington, DC 20052, USA |
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| Abstract: | BackgroundAlthough both autism spectrum disorder (ASD) and substance use disorder (SUD) are both commonly comorbid with other psychiatric conditions, there is a paucity of research on the overlap of these disorders. The primary aim of the present study was to identify the prevalence of psychiatric comorbidities in young adults with SUD and ASD compared to those with ASD only.MethodMultivariate logistic regression controlling for age was used to compare the prevalence of psychiatric disorders in a sample of treatment-seeking adult outpatients with a) ASD without SUD and b) ASD with SUD. Psychiatric and SUD diagnoses were determined by semi-structured interview (SCID for DSM IV).ResultsThe sample included 42 patients with ASD only (mean age ± SD = 26.2 ± 8.9 years) and 21 with ASD and SUD (35.2 ± 12.6). High rates of psychopathology were found in both groups. Comorbid conduct disorder (CD) was significantly more prevalent in the ASD + SUD group (25 %) compared to those without SUD (5%; p < 0.05). There were no other significant differences between groups in the rates of non-conduct comorbid psychopathology.ConclusionIn both groups, rates of psychopathology were high with CD being significantly more common in young adults with ASD and SUD. These findings highlight the importance of screening for CD in individuals with ASD to mitigate the potential development of comorbid SUD. Further research is needed to determine if CD is a true risk factor for SUD in the ASD population and identify other risk factors. |
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| Keywords: | Autism spectrum disorder ASD Substance use disorder SUD Conduct disorder |
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