| 老年社区获得性肺炎患者细胞免疫功能的变化 |
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| 引用本文： | 梁颖,米玉红,张永志,刘双.老年社区获得性肺炎患者细胞免疫功能的变化[J].中国抗感染化疗杂志,2010,10(2):112-115. |
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| 作者姓名： | 梁颖 米玉红 张永志 刘双 |
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| 作者单位： | 首都医科大学附属北京安贞医院心肺血管抢救中心EICU（呼吸组）; |
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| 摘 要： | 目的了解老年社区获得性肺炎(CAP)患者细胞免疫功能状态,初步探讨T细胞亚群在老年CAP急性期发病机制中的作用,从而为老年CAP的防治工作提供理论依据。方法采用流式细胞仪测定35例老年CAP患者和35名老年健康对照组、25例非老年CAP患者和25名非老年健康对照组,观察外周血中CD3+T细胞、CD4+T细胞、CD8+T细胞、CD4+/CD8+水平。结果1.老年CAP组CD3+T细胞比老年健康对照组增高,差异有统计学意义(P<0.05);CD4+T细胞水平比老年健康对照组降低,差异有统计学意义(P<0.05)。2.老年CAP组和非老年CAP组CD3+、CD4+、CD8+、CD4+/CD8+的比较结果显示:老年CAP组的CD3+T细胞低于非老年CAP组,差异有统计学意义(P<0.05)。3.老年健康对照组的CD3+T细胞、CD8+T细胞水平低于非老年健康对照组,其中,这两组的CD3+T细胞水平差异有明显统计学意义(P<0.01),CD8+T细胞水平差异有统计学意义(P<0.05);老年健康对照组的CD4+/CD8+水平高于非老年健康对照组,差异有明显统计学意义(P<0.01)。结论老年CAP患者急性期既存在免疫功...
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| 关 键 词： | 社区获得性肺炎 老年 CD3+T细胞 CD4+T细胞 CD8+T细胞 CD4+/CD8+ |
Changing pattern of cell immunity in elderly patients with community-acquired pneumonia |
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| LIANG Ying,MI Yuhong,ZHANG Yongzhi,LIU Shuang..Changing pattern of cell immunity in elderly patients with community-acquired pneumonia[J].Chinese Journal of Infection and Chemotherapy,2010,10(2):112-115. |
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| Authors: | LIANG Ying MI Yuhong ZHANG Yongzhi LIU Shuang |
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| Institution: | EICU/a>;Beijing Anzhen Hospital/a>;Capital Medical University/a>;Beijing 100029/a>;China |
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| Abstract: | Objective To investigate the levels of CD+3 T cell,CD+4 T cell,CD+8 T cell,CD+4 /CD+8 in peripheral blood of the elderly patients with acute community-acquired pneumonia.Methods Blood samples were collected from patients with community-acquired pneumonia(35 elderly patients,25 non-elderly patients)and healthy controls(35 normal elderly people,25 normal non-elderly people).The concentrations of CD+3 T cell,CD+4 T cell,CD+8 T cell,CD+4 /CD+8 were determined according to the method of flow cytometry.Results Th... |
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| Keywords: | community-acquired pneumonia elderly CD+3 T cell CD+4 T cell CD+8 T cell CD+4 /CD+8 |
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