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博莱霉素致肺损伤作用研究
引用本文:刘宏,赵鸣武,廖松林,王玉柱,王焕友. 博莱霉素致肺损伤作用研究[J]. 大同医学专科学校学报, 1999, 0(2)
作者姓名:刘宏  赵鸣武  廖松林  王玉柱  王焕友
作者单位:大同医专内科,北京医科大学第三医院,北京医科大学病理学系,北京医科大学第三医院,北京医科大学病理学系 037008
摘    要:为探讨使用博莱霉素的患者产生肺炎样症状和肺纤维化样症状的机理,给动物从气管内注入博莱霉素A_5,观察其对肺脏的作用。发现该药到达肺组织后,可引起明显的肺损伤。早期先引起肺泡炎,后期可导致肺纤维化。实验从病理学上揭示了博莱霉素引起肺炎样和肺纤维化样症状的原因。提示在给患者使用博莱霉素时,一旦其出现了肺炎样症状,就应及时停药并进行胸部X线检查,及时给予适当处理,以防止肺纤纤维化的发生。

关 键 词:博莱霉素  肺纤维化  肺损伤

The Study of Bleomycin Induced Lung Injury
Liu Hong,Zhao Mingwu,Liao Songlin,et al.. The Study of Bleomycin Induced Lung Injury[J]. Journal of Datong Medical College, 1999, 0(2)
Authors:Liu Hong  Zhao Mingwu  Liao Songlin  et al.
Abstract:To study the mechanism of Bleomycin induced pneumonia - like symptoms and pulmonary fibrosis-like symptoms,Bleomycin A5 was selected to do the experiment on rat models. The results showed that it can induce marked lung injury as soon as it reachs the lungs. It can induce alveolitis in early stage,and pulmonary fibrosis in late stage. It revealed the cause how Bleomycin induce pneumonia - like symptoms and pulmonary fibrosis - like symptoms according to pathology. It suggested that the patients who use Bleomycin should immediately stop using it and get their chest X-rayed as soon as pneumonia-like symptoms appear. And proper treatment should be given to them lest pulmonary fibrosis should form.
Keywords:Bleomycin Pulmonary fibrosis Lung injury
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