Effect of high-dose melphalan and peripheral blood stem cell transplantation on renal function in patients with multiple myeloma and renal insufficiency: a case report and review of the literature |
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| Authors: | E. Reiter P. Kalhs F. Keil W. Rabitsch H. Gisslinger G. Mayer N. Worel K. Lechner H. T. Greinix |
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| Affiliation: | (1) Department of Medicine I, Bone Marrow Transplantation Unit, University of Vienna, Austria, AT;(2) Division of Hematology and Hemostaseology, University of Vienna, Austria, AT;(3) Department of Medicine III, Division of Nephrology, University of Vienna, Austria, AT;(4) Department of Blood Group Serology and Transfusion Medicine, University of Vienna, Austria, AT |
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| Abstract: | Multiple myeloma with IgG-lambda monoclonal gammopathy and severe renal impairment with light-chain deposit disease was diagnosed in a 51-year-old man. Following conventional therapy with VAD (vincristine, adriamycin, dexamethasone) a partial remission was achieved. Peripheral blood stem cells (PBSC) were then collected following mobilization with cyclophosphamide and recombinant human granulocyte colony-stimulating factor and enriched for CD34-positive cells by immunoaffinity column. Fourteen months after diagnosis high-dose melphalan was given, followed by infusion of CD34-positive PBSC. Aside from mild oral mucositis and trigonitis, high-dose therapy was tolerated well. After he underwent PBSC transplantation his renal function improved, and the patient has been in in continuous complete remission for 1 year. Thus, high-dose chemotherapy can be safely administered to patients with multiple myeloma and severe renal impairment. Our findings confirm previous reports summarized in the current presentation. Received: August 3, 1998 / Accepted: November 2, 1998 |
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| Keywords: | Multiple myeloma Renal failure Peripheral blood stem cell transplantation |
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