大鼠周围神经端侧吻合后的功能评价

目的：通过研究大鼠周围神经端侧吻合后腓总神经功能指数(PFI)和电生理指标，定量评价端侧吻合后再生纤维的功能。方法：SD雄性大鼠30只，随机分为端侧吻合组和端端吻合组，端侧吻合组右侧建立胫腓神经端侧吻合模型，端端吻合组右侧建立腓神经端端吻合模型，术后2、3、5月，每组取5只测定PFI和运动神经传导速度及混合神经传导速度。结果：端侧吻合后再生神经纤维功能恢复在3个月达到高峰，但效果不如端端吻合。结论：端侧吻合可以作为神经修复的一种方法，但需慎重选择适应证。

Functional evaluation of peripheral nerve end-to-side anastomosis in rats

Objective: To study the peroneal nerve function index and electrophysiological test after peripheral nerve end-to-side anastomosis and evaluate quantificationally the function of collateral sprouting.Method:30 male SD rats were randomly divided into two groups(E-S and E-E group):In E-S group, the distal end of right peroneal nerve were end-to-side anastomosed to tibial nerve.In E-E group,right peroneal nerve were transected and sutured by end-to-end way.After 2,3,5month,PFI,MNCV and CNCV were observed.Result:Functional recovery could be found after end-to-side anastomosis and reached peak value at 3 month,but the effect is not as good as that of end-to-end anastomosis.Conclusion:The end-to-side anastomosis could be a method for the nerve repairing, however, the cases should be selected carefully.