肝硬化门静脉高压并发上消化道出血的风险因素分析

目的分析肝硬化门静脉高压并发上消化道出血的风险因素,为疾病的临床控制提供理论依据。方法收集2016年1月至2018年6月期间在阜阳市第二人民医院肝病的肝硬化门静脉高压患者180例,根据是否有消化道出血分为两组,实验组(n=90)为出血组患者,对照组(n=90)为非出血组患者。收集临床资料,并进行风险因素分析。结果两组患者年龄、性别、病程、病因、抗病毒治疗史等一般资料无明显差异(P>0.05)。实验组患者胃底静脉曲张>5 mm例数大于对照组,差异具有统计学意义(P<0.05),两组患者不同程度红色征的例数均有显著差异(P<0.05)。实验组门静脉内径、脾静脉内径均大于对照组,差异具有统计学意义(P<0.05)。实验组患者肝功能分级高于对照组,差异具有统计学意义(P<0.05)。结论肝硬化门静脉高压并发上消化道出血的风险因素有性别因素、胃底静脉曲张程度、门静脉和脾静脉内径增大、肝功能Child-Pugh分级较高等,提示我们日常应完善肝硬化患者的体检工作,并针对风险较高的患者及时给与积极的治疗措施。

Risk Factors of Portal Hypertension Complicated with Upper Gastrointestinal Bleeding in Hepatic Cirrhosis

Objective To analyze the risk factors of portal hypertension complicated with upper gastrointestinal bleeding in hepatic cirrhosis, and to provide theoretical basis for clinical control of the disease. Methods A total of 180 patients with portal hypertension in hepatic cirrhosis were collected from portal hypertension in hepatic cirrhosis in the Second People's Hospital of Fuyang from January 2016 to June 2018. They were divided into two groups according to whether there was gastrointestinal bleeding. The experimental group ( n =90) was the bleeding group, and the control group ( n =90) was the non-bleeding group. We collected clinical data and analyzed risk factors. Results There was no significant difference between the two groups in age, gender, course of disease, etiology and history of antiviral therapy ( P >0.05).The number of patients with gastric varices >5 mm in the experimental group was higher than that in the control group, and the difference was statistically significant ( P <0.05). The number of patients with different degrees of red signs in the two groups were significantly different ( P <0.05).The diameter of portal vein and splenic vein in the experimental group was larger than that in the control group, and the difference was statistically significant ( P <0.05).The Child-Pugh grade of the experimental group was higher than that of the control group,and the difference was statistically significant ( P <0.05). Conclusion Risk factors for liver cirrhosis portal hypertension complicated with upper gastrointestinal hemorrhage have gender factors, the degree of gastric varices,portal vein and splenic vein diameter increases and the high Child-Pugh grade, which prompt us that we should improve the physical examination in patients with cirrhosis,and give positive therapy measures in time for the high risk patients.