HLA‐A*11:53 is shown to be identical to the corrected A*11:02:01 allele sequence |
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| Authors: | P. Y. Lin |
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| Affiliation: | Laboratory of Immunogenetics, Tzu Chi Stem Cells Centre, Buddhist Tzu Chi Marrow Donor Registry, Buddhist Tzu Chi General Hospital, Buddhist Compassion Relief Tzu Chi Foundation, Hualien, Taiwan |
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| Abstract: | According to the IMGT/HLA Database, the DNA sequence of A*11:53 is identical to A*11:02:01 in exons 2, 3, 4 and 5 except at codon 276. A*11:53 was reported as a rare variant of A*11, while A*11:02:01 was understood to be the second most frequently observed variant of A*11 after A*11:01:01 in Taiwanese. We sequenced HLA‐A locus exons 2, 3, 4 and 5 of Taiwanese blood donors (n = 50) previously typed to carry A*11:02:01. We found out all of their sequences are identical to A*11:53 in exons 2, 3, 4 and 5′ part of exon 5 including codon 276. |
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