Implant Osseointegration in Circumferential Bone Defects Treated with Latex‐Derived Proteins or Autogenous Bone in Dog's Mandible |
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| Authors: | Maya Fernanda Manfrin Arnez DDS MS Samuel Porfírio Xavier DDS MS PhD Paulo Esteves Pinto Faria DDS MS Wagner Fernandes Pedrosa Júnior DDS MS Tatiana Ramirez Cunha DDS Ricardo José de Mendonça DDS MS PhD Joaquim Coutinho‐Netto DDS MS PhD Luiz Antonio Salata DDS MS PhD |
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| Affiliation: | 1. Master in oral and maxillofacial surgery, Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeirao Preto, University of S?o Paulo, Ribeir?o Preto, S?o Paulo, Brazil;2. professor, Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeirao Preto, University of S?o Paulo, Ribeir?o Preto, S?o Paulo, Brazil;3. PhD student, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry of Ara?atuba, University of the State of S?o Paulo, Ara?atuba, S?o Paulo, Brazil;4. Master in oral and maxillofacial surgery, Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeir?o Preto, University of S?o Paulo, Ribeir?o Preto, S?o Paulo, Brazil;5. Bachelor in dental science, Department of Biochemistry and Immunology, Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, Ribeir?o Preto, S?o Paulo, Brazil;6. postdoctorate student, Department of Biochemistry and Immunology, Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, Ribeir?o Preto, S?o Paulo, Brazil;7. associate professor, Department of Biochemistry and Immunology, Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, Ribeir?o Preto, S?o Paulo, Brazil;8. associate professor, Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeir?o Preto, University of S?o Paulo, Ribeir?o Preto, S?o Paulo, Brazil |
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| Abstract: | Background: In sites with diminished bone volume, the osseointegration of dental implants can be compromised. Innovative biomaterials have been developed to aid successful osseointegration outcomes. Purpose: The aim of this study was to evaluate the osteogenic potential of angiogenic latex proteins for improved bone formation and osseointegration of dental implants. Materials and Methods: Ten dogs were submitted to bilateral circumferential defects (5.0 × 6.3 mm) in the mandible. Dental implant (3.3 × 10.0 mm, TiUnite MK3?, Nobel Biocare AB, Göteborg, Sweden) was installed in the center of the defects. The gap was filled either with coagulum (Cg), autogenous bone graft (BG), or latex angiogenic proteins pool (LPP). Five animals were sacrificed after 4 weeks and 12 weeks, respectively. Implant stability was evaluated using resonance frequency analysis (Osstell Mentor?, Osstell AB, Göteborg, Sweden), and bone formation was analyzed by histological and histometric analysis. Results: LPP showed bone regeneration similar to BG and Cg at 4 weeks and 12 weeks, respectively (p ≥ .05). Bone formation, osseointegration, and implant stability improved significantly from 4 to 12 weeks (p ≤ .05). Conclusion: Based on methodological limitations of this study, Cg alone delivers higher bone formation in the defect as compared with BG at 12 weeks; compared with Cg and BG, the treatment with LPP exhibits no advantage in terms of osteogenic potential in this experimental model, although overall osseointegration was not affected by the treatments employed in this study. |
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| Keywords: | bone regeneration circumferential bone defects Hevea brasiliensis implant osseointegration latex proteins |
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