Pediatric Liver Transplantation Using Reduced and Hyper‐Reduced Left Lateral Segment Grafts: A 10‐Year Single‐Center Experience |
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Authors: | M R Shehata S Yagi Y Okamura T Iida T Hori A Yoshizawa K Hata Y Fujimoto K Ogawa S Okamoto Y Ogura A Mori S Teramukai T Kaido S Uemoto |
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Institution: | 1. Department of Hepatobiliary, Pancreas and Transplant Surgery, Kyoto University, Kyoto, Japan;2. Department of Clinical Trial Design and Management Translational Research Center, Kyoto University, Kyoto, Japan |
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Abstract: | Few studies have examined the long‐term outcomes and prognostic factors associated with pediatric living living‐donor liver transplantation (LDLT) using reduced and hyper‐reduced left lateral segment grafts. We conducted a retrospective, single‐center assessment of the outcomes of this procedure, as well as clinical factors that influenced graft and patient survival. Between September 2000 and December 2009, 49 patients (median age: 7 months, weight: 5.45 kg) underwent LDLT using reduced (partial left lateral segment; n = 5, monosegment; n = 26), or hyper‐reduced (reduced monosegment grafts; n = 18) left lateral segment grafts. In all cases, the estimated graft‐to‐recipient body weight ratio of the left lateral segment was more than 4%, as assessed by preoperative computed tomography volumetry, and therefore further reduction was required. A hepatic artery thrombosis occurred in two patients (4.1%). Portal venous complications occurred in eight patients (16.3%). The overall patient survival rate at 1, 3 and 10 years after LDLT were 83.7%, 81.4% and 78.9%, respectively. Multivariate analysis revealed that recipient age of less than 2 months and warm ischemic time of more than 40 min affected patient survival. Pediatric LDLT using reduced and hyper‐reduced left lateral segment grafts appears to be a feasible option with acceptable graft survival and vascular complication rates. |
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Keywords: | Living‐donor liver transplantation monosegment partial left lateral segment graft reduced and hyper‐reduced graft |
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