| 预防性应用吡格列酮改善胰岛素抵抗的脂肪内分泌机制 |
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| 引用本文： | 龚燕平,李春霖,田慧,母义明,陆菊明,肖彧君,潘长玉.预防性应用吡格列酮改善胰岛素抵抗的脂肪内分泌机制[J].山东医药,2010,50(16):27-29. |
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| 作者姓名： | 龚燕平 李春霖 田慧 母义明 陆菊明 肖彧君 潘长玉 |
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| 作者单位： | 中国人民解放军总医院,北京,100853 |
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| 摘 要： | 目的探讨吡格列酮改善胰岛素抵抗过程中脂肪内分泌功能的改变。方法45只W istar雄性大鼠随机分为对照组、胰岛素抵抗组和吡格列酮组。胰岛素抵抗动物模型成功建立后,分析各组抵抗素、脂联素和脂联素受体的表达。结果与胰岛素抵抗组比较,吡格列酮组大鼠的体质量、空腹血糖、游离脂肪酸差异不明显,但胰岛素、胰岛素抵抗指数、葡萄糖耐量和胰岛素耐量明显改善（P〈0.01）,脂联素表达明显增高（P〈0.05）。结论脂肪内分泌功能紊乱在高脂诱导胰岛素抵抗的发生中起着重要的作用,预防性应用吡格列酮可明显延缓大鼠胰岛素抵抗的发生,改善脂肪内分泌功能。
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| 关 键 词： | 脂联素 脂联素受体 抵抗素 吡格列酮 胰岛素抵抗 |
Change of fat tissue endocrine function during pioglitazone treatment on fat-fed induced insulin resistance |
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| GONG Yan-ping,LI Chun-lin,TIAN Hui,MU Yi-ming,LU Ju-ming,XIAO Yi-jun,PAN Chang-yu.Change of fat tissue endocrine function during pioglitazone treatment on fat-fed induced insulin resistance[J].Shandong Medical Journal,2010,50(16):27-29. |
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| Authors: | GONG Yan-ping LI Chun-lin TIAN Hui MU Yi-ming LU Ju-ming XIAO Yi-jun PAN Chang-yu |
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| Institution: | GONG Yan-ping,LI Chun-lin,TIAN Hui,MU Yi-ming,LU Ju-ming,XIAO Yu-jun,PAN Chang-yu (The General Hospital of Chinese People\'s Liberation Army,Beijing 100853,P.R.China) |
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| Abstract: | Objective To observe the mechanism of fat tissue endocrine function during pioglitazone treatment on fat-fed induced insulin resistance(IR).Methods A total of 45 wistar male rats were randomly distributed into 3 groups: control,IR and pioglitazone group.When IR was confirmed,the expression of resistin,adiponectin and adiponectin R1 was analyzed,respectively.Results Compared with IR group,insulin,HOMA-IR,glucose tolerance and insulin tolerance in pioglitazone group were obviously improved(P<0.01),there were ... |
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| Keywords: | adiponectin adiponectin receptor resistin pioglitazone insulin resistance |
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