摘 要: | 目的:探讨钙敏感受体(calcium-sensing receptor,CaSR)基因多态性与江西赣南地区含钙肾结石(calcium nephrolithiasis,CN)的相关性。方法:采用实时荧光定量聚合酶链式反应(real-time polymerase chain reaction,Real-time PCR)TaqMan-MGB探针法检测赣南地区220例含钙肾结石患者(CN组)和250例健康人群(对照组)CaSR基因rs9740、rs1501899、rs3749207、rs4678174、rs6776158、rs7652589、rs1042636、rs1801725、rs1801726、rs7632399和rs9883981位点单核苷酸多态性(single nucleotide polymorphism,SNP),同时检测两组人群血钙和尿钙,应用R语言中SNPassoc 1.9-2和Haplo.stats 2.17.0软件分析CaSR基因型和单体型与含钙肾结石的相关性。结果:CN组中rs1501899位点的A等位基因频率高于对照组(P<0.001);与对照组相比,CN组...
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