住院肺癌患者抑郁状况危险因素及其对生活质量的影响

目的本研究探索住院肺癌患者抑郁状况及其对健康相关生活质量(health-related quality of life,HRQOL)的影响。方法纳入了2016年6月至2018年6月期间就诊于本院的120例肺癌患者,所有患者均行医院焦虑抑郁量表和世界卫生组织生活质量量表简表调查问卷并记录其一般临床信息,分析抑郁情绪与患者HRQOL关系。结果所有患者中,共52例(43.3%)有抑郁症状。中重度疼痛(OR:4.43,95%CI:1.81, 10.85)、伴有远处转移(OR:3.63,95%CI:1.20,10.98)、更长的肺癌确诊(OR:1.04,95%CI:1.01,1.07)、更差的ECOG-PS评分(OR:3.41,95%CI:1.24,9.35)和小细胞肺癌(OR:4.52,95%CI:1.65,12.35)可增加患者抑郁的风险。WHOQOL-BREF评分显著下降。结论抑郁情绪在肺癌住院患者中普遍存在,并与不良的生活质量独立相关,医护人员应提供有效的疼痛管理和心理服务。

Risk factors of depression status in hospitalized lung cancer patients and their impact on quality of life

Objective To explore depression status in hospitalized lung cancer patients and their impact on patients health-related quality of life(HRQOL).Methods A total of 120 inpatients from June 2016 to June 2018 were consecutively recruited,and administered with a standardized questionnaire to collect socio-demographic and clinical data.Depression and HRQOL were assessed with the Hospital Anxiety and Depression Scale and World Health Organization QOL Scale Brief version,respectively.Results As high as 43.3%lung cancer inpatients had clinically significant depressive symptoms.Multiple logistic regression found that depression was significantly associated with moderate-to-severe pain(OR:4.43,95%CI:1.81,10.85),metastatic cancer(OR:3.63,95%CI:1.20,10.98),a short duration after cancer diagnosis(OR:1.04,95%CI:1.01,1.07),poor performance status(OR:3.41,95%CI:1.24,9.35),and small-cell cancer(OR:4.52,95%CI:1.65,12.35).Depressed patients had significantly poorer HRQOL than non-depressed patients in terms of all four domains of HRQOL.After controlling for the potential confounding effects of socio-demographic and clinical factors with analysis of covariance,these group-differences in HRQOL remained statistically significant.Conclusion Depression is prevalent in inpatients with lung cancer and independently associated with poor HRQOL.