高血压患者血清MMP-2、TIMP-2、Hcy、UA水平与颈动脉硬化的相关性

目的 探讨高血压患者血清基质金属蛋白酶2（MMP 2）、基质金属蛋白酶抑制剂2（TIMP 2）、同型半胱氨酸（Hcy）、尿酸（UA）水平与颈动脉内中膜厚度（cIMT）的相关性。方法 应用多普勒超声检测364例高血压病患者的cIMT, 根据cIMT是否≥1 mm分为cIMT增厚组和cIMT无增厚组;酶联免疫法测定患者血清MMP 2、TIMP 2,同时送检验科测定血清Hcy、UA及血脂水平。分析颈动脉内中膜增厚的独立危险因素。结果 与cIMT无增厚组比较,cIMT增厚组年龄、Hcy、UA、MMP 2增加(P<0.05)。cIMT与UA、MMP 2、年龄呈正相关。年龄是颈动脉内中膜增厚的独立危险因素。结论 年龄是动脉硬化的独立危险因素,MMP 2、Hcy、TC、LDL c、UA与动脉硬化有关,但目前尚不能确定为动脉硬化的独立损害因子。

Correlation analysis of serum levels of MMP-2, TIMP-2, Hcy,UA and carotid atherosclerosis in patients with hypertension

Objective To investigate the correlation between serum levels of matrix metalloproteinase 2 (MMP 2), matrix metalloproteinase inhibitor 2 (TIMP 2), homocysteine (Hcy), uric acid (UA) and carotid intima media thickness (cIMT) in patients with hypertension.Methods Doppler ultrasound was used to detect cIMT in 364 patients with hypertension. According to whether cIMT ≥1 mm, the patients were divided into cIMT thickening group and cIMT non thickening group. The serum MMP 2 and TIMP 2 were measured by enzyme linked immunoassay, and the serum Hcy, UA and lipid levels were determined by laboratory at the same time. The independent risk factors for carotid intima thickening were analyzed. Results Compared with cIMT non thickening group, the age, Hcy, UA and MMP 2 increased in cIMT thickening group(P<0.05). Age was an independent risk factor for carotid intima thickening. Conclusion Age is an independent risk factor for atherosclerosis. MMP 2, Hcy, TC, LDL C and UA are associated with atherosclerosis, but they can not be identified as independent damage factors for atherosclerosis at present.