手足口病后甲损害212例临床研究

目的:探讨手足口病后甲损害与微量元素之间的相关性。方法:回顾性研究2015年5月-2016年5月我科门诊就诊的212例手足口病后甲损害的患儿临床资料和微量元素检测结果,并与国内外文献相对比,探寻其发病诱因。结果:212例手足口病后甲损害患儿中男女比例1.12∶1,平均年龄(58.55±36.42)个月。手足口病与甲损害症状出现的间隔时间为(68.94±59.53)d,手足口发病后5~6周为手足口病后甲损害的高发时间段,具有统计学差异(P<0.05)。109例(51.42%)出现血锌缺乏,39例(18.40%)出现血清铁缺乏,12例(5.66%)出现血钙缺乏。212例患者平均血铜(18.16±3.32)μmol/L(P>0.05);血钙(1.69±0.11)mmol/L(P>0.05);血镁(1.58±0.12)mmol/L(P>0.05),血铁(7.98±0.60)mmol/L(P>0.05),血铅(32.18±24.61)μg/L(P>0.05),血镉(1.65±1.26)μg/L(P>0.05),血锌(70.64±13.19)μmol/L(P>0.05)。结论:甲损害为手足口病的后期并发症,但与微量元素是否缺乏无明显相关性。

Correlation of onychomadesis after hand-foot-and-mouth-disease and trace elements:a retrospective study of 212 cases

Objective: To study the relationship between onychomadesis after hand-foot-and-mouth-disease and trace elements. Method: A retrospective analysis was performed to analyze the clinical data of 212 cases with onychomadesis after hand-foot-and-mouth-disease and their trace elements from May 2015 to May 2016. Results: The male/female ratio was 1.12 to 1, with the average age of onset of(58.55±36.42) months. Following hand-foot-and-mouth disease, average times to develop onycholmadesis were(68.94±59.53) days, with the highest incidence between(4~6) weeks(P<0.05). Deficiencies in zinc, iron and calcium accounted for 51.42%(109 cases), 18.4%(39 cases), and 5.66%(12 cases), respectively. Average blood levels of minerals were(18.16±3.32) μmol/L for copper,(1.69±0.11) mmol/L for calcimu,(1.58±0.12) mmol/L for magnesium,(7.98±0.60) mmol/L for iron,(32.18±24.61) μg/L for lead,(1.65±1.26) μg/L for cadmium, and(70.64±13.19) μmol/L for zinc. Conclusion: Onychomadesis might be a late complication of hang-foot-and-mouth-disease with no correlation with trace elements.