氟桂利嗪联合经皮神经电刺激治疗前庭型偏头痛的效果及安全性研究

目的探讨氟桂利嗪联合经皮神经电刺激(transcutaneouselectrical nerve stimulation,TENS)治疗前庭型偏头痛(vestibular migraine,VM)的效果及安全性。方法选取我院2018年2月-2019年3月收治的VM患者124例,根据治疗方法的不同分为观察组63例和对照组61例。观察组予氟桂利嗪联合TENS治疗,对照组仅予氟桂利嗪治疗,疗程均为3个月。治疗结束后比较两组临床疗效;观察两组治疗前及治疗后随访2个月首次发作头痛、眩晕程度,头痛程度采用视觉模拟量表(visual analogue scale,VAS)评估,眩晕程度采用眩晕障碍量表(dizziness handicap inventory,DHI)评估;比较两组治疗前及治疗后随访2个月头痛、眩晕发作频率和持续时间;比较两组治疗前及治疗结束时两组生活质量评价量表(short form 36 questionnaire,SF-36)评分;观察两组治疗期间不良反应发生情况。结果治疗后观察组总有效率为92.06%高于对照组总有效率62.30%(P<0.01);治疗后随访2个月首次发作时两组VAS评分和DHI评分均较治疗前改善,且观察组VAS评分和DHI评分改善程度大于对照组,差异均有统计学意义(P<0.05或P<0.01);治疗后随访2个月两组头痛、眩晕发作频率和持续时间均较治疗前改善,且观察组头痛、眩晕发作频率和持续时间改善程度均大于对照组,差异均有统计学意义(P<0.05或P<0.01);治疗结束时两组SF-36评分均较治疗前升高,且观察组SF-36评分升高程度大于对照组,差异均有统计学意义(P<0.05或P<0.01);两组治疗期间总不良反应发生率比较差异无统计学意义(P>0.05)。结论氟桂利嗪联合TENS治疗VM可显著提高患者临床疗效,改善患者头痛及眩晕的程度、发作频率和持续时间,提高患者生活质量,且治疗安全性较好。

Efficacy and Safety of Flunarizine Combined with Percutaneous Nerve Electrical Stimulation in the Treatment of Vestibular Migraine

Objective To investigate the efficacy and safety of transcutaneous nerve stimulation(TENS)in the treatment of vestibular migraine(VM).Methods 124 patients with VM admitted to Cangzhou Central Hospital from February 2018 to March 2019 were selected and randomly divided into observation group(63 cases)and control group(61 cases).The observation group was treated with flunarizine combined with TENS,while the control group was treated with flunarizine only for 3 months.After treatment,the clinical efficacy of the two groups was compared;the degree of headache and vertigo before and after treatment,the degree of headache was assessed by visual analogue scale(VAS),and the degree of vertigo was assessed by dizziness handicap inventory(DHI);the treatment and treatment before treatment were compared between the two groups.The frequency and duration of headache and vertigo attacks were followed up for 2 months after treatment.The scores of SF-36 were compared between the two groups before treatment and at the end of treatment.The occurrence of adverse reactions during treatment was observed.Results After treatment,the total effective rate of the observation group was 92.06%higher than that of the control group(62.30%,P<0.01).At the end of treatment,the VAS score and DHI score of the two groups were improved,and the improvement of the VAS score and DHI score of the observation group was greater than that of the control group(P<0.05 or P<0.01).The frequency and duration of headache and vertigo attacks in the observation group were higher than those in the control group(P<0.05 or P<0.01).At the end of treatment,the SF-36 scores of the two groups were higher than those before treatment,and the difference was statistically significant(P<0.05 or P<0.01).The SF-36 score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05 or P<0.01);there was no significant difference in the incidence of total adverse reactions between the two groups during the treatment period(P>0.05).Conclusion Flunarizine combined with TENS can significantly improve the clinical efficacy of patients with vestibular migraine,improve the degree,frequency and duration of headache and vertigo,improve the quality of life of patients,and the treatment is safe.