缺血性脑梗死患者血清同型半胱氨酸水平与性别、高血压、亚甲基四氢叶酸还原酶基因的关系

目的探讨同型半胱氨酸(Hcy)水平与性别、高血压和亚甲基四氢叶酸还原酶(MTHFR)基因的关系。方法检测229例脑梗死患者和111例非脑梗死患者的血清Hcy水平和MTHFR基因型,比较血清Hcy在不同性别、高血压及MTHFR基因型患者之间的差别。结果脑梗死组T等位基因频率显著高于非脑梗死组(χ^2=4.98,P=0.026)。脑梗死组中,TT基因型患者的Hcy水平显著高于CC和CT基因型患者(P<0.05~0.01)。非脑梗死组中,TT基因型患者的Hcy水平显著高于CC和CT基因型的患者(均P<0.01)。脑梗死组CC、CT、TT基因型患者的Hcy水平均显著高于非脑梗组(t=4.21,P<0.01;t=4.20,P<0.01;t=2.20,P=0.033)。两组间高血压患者的Hcy水平均显著高于无高血压患者(均P<0.01),男性Hcy水平均显著高于女性(均P<0.01)。结论脑梗死患者具有较高的T等位基因频率。TT基因型、男性、高血压患者具有较高的Hcy水平。

The relationship between serum homocysteine level and gender,hypertension,MTHFR gene in patients with ischemic cerebral infarction

Objective To investigate the relationship between homocysteine(Hcy)level and gender,hypertension,methylenetetrahydrofolate reductase(MTHFR)gene.Methods Serum Hcy level and MTHFR genotypes were measured in 229 patients with cerebral infarction and 111 non-cerebral infarction patients.The difference of serum Hcy in patients with different gender,hypertension and MTHFR genotype were compared.Results The frequency of T allele in cerebral infarction group was significantly higher than that in non-cerebral infarction group(χ^2=4.98,P=0.026).In cerebral infarction group,the Hcy level of TT genotype patients was significantly higher than that of CC and CT genotype patients(P<0.05-0.01).In the non-cerebral infarction group,the Hcy level of TT genotype patients was significantly higher than that of CC and CT genotypes(all P<0.01).The levels of Hcy in patients with CC,CT and TT genotypes in cerebral infarction group were significantly higher than those in noncerebral infarction group(t=4.21,P<0.01;t=4.20,P<0.01;t=2.20,P=0.033).Between the two groups,the level of Hcy in hypertension patients was significantly higher than that in non-hypertension patients(all P<0.01),and the level of Hcy in male was significantly higher than that in female(all P<0.01).Conclusions Patients with cerebral infarction have higher T allele frequency.TT genotype,male and hypertension patients have higher Hcy level.