类风湿关节炎合并肺间质性病变的临床特点及与抗环瓜氨酸肽抗体的相关性研究

目的研究类风湿关节炎合并肺间质性病变的临床特点及与抗环瓜氨酸肽抗体的相关性。方法随机选择2015年10月到2016年10月之间于河北北方学院附属第一医院就诊的RA患者和RA-ILD患者各40例进行本次研究,所有患者来诊后当日均予类风湿因子(RF)、抗CCP抗体、C反应蛋白(CRP)、血沉(ESR)、血小板(PT)、IgA、IgG、C3、C4等实验室检查。比较两组患者一般资料、实验室指标之间的差异,观察影响ILD发病的相关因素,观察两组患者在不同滴度范围内所占比例,使用Pearson相关性分析,观察抗CCP抗体滴度和各指标之间的相关性。结果 RA-ILD组患者年龄、吸烟比例、病程、累及关节数量均高于RA组,且具有统计学差异(P<0.05),RA-ILD组患者CCP水平高于RA组,且具有统计学差异(P<0.05)。以患者是否并发ILD为因变量对患者进行Logistic多因素回归分析,结果发现年龄、吸烟以及CCP水平是影响RA患者并发ILD的独立危险因素。RA-ILD组患者≥300 IU/mL CCP抗体滴度所占比例为42.50%,明显高于RA组,且具有统计学差异(P<0.05),抗CCP抗体滴度与患者年龄、吸烟、病程、累及关节均无相关性(P>0.05)。结论 RA-ILD患者以年龄较高、有吸烟史、CCP水平较高为主要临床特点,CCP抗体滴度≥300 IU/mL的患者更容易并发ILD,但是抗CCP抗体滴度与影响患者并发ILD的因素并无相关性。

Clinical characteristics of rheumatoid arthritis with pulmonary interstitial lesions and its correlation with anti-cyclic citrullinated peptide antibodies

Objective To study the clinical characteristics of rheumatoid arthritis with pulmonary interstitial lesions and the correlation with anti-cyclic citrullinated peptide antibodies.Methods 40 patients with RA and RA-ILD were randomly selected from October 2015 to October 2016.All patients were given rheumatoid factor(RF),anti CCP antibody,C reactive protein(CRP),erythrocyte sedimentation rate(ESR),platelet(PT),IgA,IgG,C3,and so on on the day after diagnosis.The differences of general data and laboratory indicators between the two groups were compared,and the related factors affecting the incidence of ILD were observed.The proportion of patients in the two groups in different titers was observed.Pearson correlation analysis was used to observe the correlation between anti-CCP antibody titers and indicators.Results The age,smoking rate,course of disease and number of joints involved in the RA-ILD group were higher than those in the RA group,and there were statistical differences(P<0.05).The level of CCP in the RA-ILD group was higher than that in the RA group,and there were statistical differences(P<0.05).Logistic multivariate regression analysis was carried out on the patients with or without ILD as dependent variable.The results showed that age,smoking and CCP level were the influencing factors of RA complicated with ILD.The percentage of CCP antibody titers in the RA-ILD group(>300 IU/mL)was 42.50%,which was significantly higher than that in the RA group(P<0.05).There was no correlation between anti-CCP antibody titers and age,smoking,course of disease and joint involvement(P>0.05).Conclusion The main clinical characteristics of RA-ILD patients are higher age,smoking history and higher CCP level.Patients with CCP antibody titer(>300 IU/mL)are more likely to develop ILD,but there is no correlation between anti-CCP antibody titer and the factors affecting ILD.