| HBV持续感染及其机制的研究进展 |
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| 引用本文： | 陈欢,杨燕卿,储君,张国远,林世德.HBV持续感染及其机制的研究进展[J].临床肝胆病杂志,2020,36(1):174-177. |
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| 作者姓名： | 陈欢 杨燕卿 储君 张国远 林世德 |
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| 作者单位： | 遵义医科大学附属医院感染科,贵州遵义563003 |
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| 基金项目： | 国家自然科学基金(814600124/H0316) |
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| 摘 要： | HBV属嗜肝DNA病毒科,可引起人类急性和慢性肝炎,甚至肝硬化、肝癌。目前的抗病毒药物因不能彻底清除肝细胞内HBV,故很难达到治愈的效果。近年来,HBV持续感染的机制受到广泛关注,主要涉及宿主与病毒两方面,从病毒方面展开,主要阐述了cccDNA、HBV颗粒和HBV自身组分维持HBV持续感染的相关研究进展。
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| 关 键 词： | 乙型肝炎病毒 乙型肝炎表面抗原 乙型肝炎e抗原 乙型肝炎核心抗原 DNA 环状 |
Research advances in persistent hepatitis B virus infection and its mechanism |
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| Institution: | (Department of Infectious Diseases,The Affiliated Hospital of Zunyi Medical University,Zu nyi,Guizhou 563003,China) |
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| Abstract: | Hepatitis B virus(HBV) belongs to the Hepadnaviridae family and can cause acute and chronic hepatitis,liver cirrhosis,and even liver cancer in humans. Current antiviral drugs cannot completely eliminate HBV in liver cells and thus it is difficult to achieve a curative effect. In recent years,the mechanism of persistent HBV infection has attracted wide attention,which mainly involves host and virus. This article elaborates on the research advances in persistent HBV infection from the aspect of virus,including covalently closed circular DNA,HBV particles,and HBV components. |
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| Keywords: | hepatitis B virus hepatitis B surface antigen hepatitis B e antigen hepatitis B core antigen DNA circular |
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