肥胖症儿童临床相关因素

目的 通过对肥胖症儿童血脂、空腹血糖、空腹胰岛素、肝功能、肝脏彩超进行分析研究，探讨肥胖症儿童相关并发症高血压、非酒精性脂肪肝、糖代谢异常、血脂紊乱的发生情况，以帮助早期识别和干预。方法 通过对103例肥胖症儿童间进行体格检查，检测血脂、肝功能、空腹血糖、空腹胰岛素、餐后2 h血糖、肝脏彩超等检查结果进行临床分析。结果 本次调查发现3组肥胖儿童的甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、舒张压及收缩压、胰岛素抵抗指数差异有统计学意义(P＜0.05)。随体重的增加非高密度脂蛋白胆固醇血压及胰岛素抵抗指数呈上升趋势，而高密度脂蛋白胆固醇有所减低。103例肥胖症儿童并发高血压19例（18.4%)；血脂紊乱36例(35.0%)；糖代谢异常18例（17.5%），其中2型糖尿病2例（1.9%），该2型糖尿病患儿为中、重度肥胖症者。并发非酒精性脂肪肝24例（23.3%），其中有肝功能异常14例（13.6%）。结论 儿童肥胖症会引起血糖、血脂指标异常、胰岛素抵抗等现象，使儿童患高血压、非酒精性脂肪肝及糖尿病等疾病的风险增加。肥胖儿童要减轻体重，定期体检，以此调节其各项指标的水平，降低由肥胖导致的各种并发症的发生率。

Clinical related factors of obese children

Objective To investigate the incidence of hypertension,non-alcoholic fatty liver disease,abnormal glucose metabolism,and blood lipid disorders in obese children by analyzing the blood lipids,fasting blood glucose,fasting insulin,liver function,and liver color Doppler ultrasound,to help early identification and intervention of childhood obesity.Methods Physical examination was performed on 103 obese children,thenthe testing results of their blood lipids,liver function,fasting blood glucose,fasting insulin,2 h postprandial blood glucose,and liver ultrasound were analyzed.Results The survey found that there were statistically significant differences in triglyceride,total cholesterol,high density lipoprotein(HDL),low density lipoprotein,diastolic and systolic blood pressure,and insulin resistance index among three groups of obese children(P<0.05).With the increase of body weight,non-HDL-C,blood pressure,and insulin resistance index showed an upward trend,while HDL-C decreased.Of 103 obese children,19(18.4%)had hypertension;36(35.0%)had dyslipidemia;18(175.5%)had abnormal glucose metabolism,of which,2 cases(1.9%)had type 2 diabetes,and children with the type 2 diabetes were moderately to severely.There were 24 patients(23.3%)with non-alcoholic fatty liver,including 14(13.6%)with abnormal liver function.Conclusion Childhood obesity can cause blood glucose,abnormal blood lipids,insulin resistance,which increases the risk of hypertension,non-alcoholic fatty liver and diabetes in children.The obese childern must lose their weight and do regular physical examinations to adjust the levels of various indicators and reduce the incidence of various complications caused by obesity.