实时剪切波弹性成像对前列腺增生患者口服用药治疗的评估

目的通过检测前列腺增生患者口服用药前后前列腺移行区和周围区组织弹性模量的变化,探讨实时剪切波弹性成像评价前列腺增生患者药物治疗效果的临床应用价值。方法选取前列腺增生口服药物治疗的患者175例,应用经直肠实时剪切波弹性成像测量移行区和周围区前列腺组织的弹性模量,比较用药前后患者前列腺组织移行区和周围区弹性模量的变化,分析前列腺组织移行区和周围区弹性模量与患者国际前列腺症状(IPSS)评分、生活质量(QOL)评分、最大尿流率、前列腺体积、剩余尿量的相关性。结果口服用药前患者前列腺组织移行区和周围区弹性模量分别为(60.17±5.86)kPa和(24.82±3.03)kPa,用药后分别为(40.23±5.84)kPa和(15.14±2.93)kPa,差异均有统计学意义(均P<0.05)。前列腺组织移行区弹性模量与IPSS评分、QOL评分、最大尿流率、前列腺体积、剩余尿量均相关(r=0.69、0.84、-0.73、0.53、0.74,均P<0.05),前列腺周围区组织弹性模量与IPSS评分、QOL评分、最大尿流率、前列腺体积、剩余尿量亦均相关(r=0.58、0.72、-0.58、0.44、0.55,均P<0.05)。结论实时剪切波弹性成像能够较准确地测量前列腺增生患者口服用药前后的前列腺组织硬度,有效评估药物治疗前列腺增生的治疗效果,具有较好的临床应用价值。

Evaluation of treatment effect of medicine in prostatic hypertrophy patients by real-time shear wave elastography

ObjectiveTo compare the changes of Young’s modulus of transitional and peripheral zone of prostate in benign prostatic hyperplasia patients after medicine treatment,and to investigate the clinical value of real-time shear wave elastography in the evaluation of the therapeutic effect.MethodsA total of 175 patients with benign prostatic hyperplasia who underwent transrectal shear wave elastography were selected.Young’s modulus of transitional zone and peripheral zone of prostate were measured by real-time shear wave elastography before and after medicine treatment. Young’s modulus of transitional zone and peripheral zone of prostate were compared and their correlation with international prostate symptom score(IPSS),quality of life(QOL)score,maximum flow rate of urine(Qmax),prostate volume(PV),post void residual(PVR)were evaluated.ResultsThe mean Young’s modulus of prostate transitional zone and peripheral zone were from(60.17±5.86)kPa、(24.82±3.03)kPa to(40.23±5.84)、(15.14±2.93)kPa before and after medicine treatment,respectively,with statistical significance(both P<0.05).Young’s modulus of transitional zone showed a significant correlation with IPSS,QOL,Qmax,PV,PVR(r=0.69,0.84,-0.73,0.53,0.74,all P<0.05),and Young’s modulus of prostate peripheral zone showed a weak correlation with IPSS,QOL,Qmax,PV,PVR(r=0.58,0.72,-0.58,0.44,0.55,all P<0.05).ConclusionShear wave elastography could provide the information of prostate hardness before and after medicine treatment.It is an effective way to evaluate the treatment value and has good clinical application value.