知柏地黄口服液联合丙硫氧嘧啶辅治甲状腺功能亢进症的效果及对甲状腺激素、抗氧化指标的影响

目的观察知柏地黄口服液联合丙硫氧嘧啶辅治甲状腺功能亢进症(甲亢)的效果及对甲状腺激素、抗氧化指标的影响。方法选取2017年3月-2018年4月我院收治82例甲亢患者作为研究对象,根据治疗方案的不同均分为观察组和对照组。对照组给予丙硫氧嘧啶、普萘洛尔片治疗,观察组在对照组治疗基础上加用知柏地黄口服液治疗。比较两组治疗12周后临床效果,治疗前及治疗12周后游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和抗氧化指标[超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPX)、丙二醛(MDA)]水平,以及治疗过程中不良反应发生情况。结果观察组临床总有效率为97.56%显著高于对照组总有效率的82.93%(P<0.05)。两组治疗后FT3、FT4水平较治疗前显著下降,且观察组FT3、FT4降低程度显著大于对照组,差异均有统计学意义(P<0.05或P<0.01)。治疗后,两组SOD、GPX水平明显高于治疗前,MDA水平明显低于治疗前,且治疗后观察组SOD、GPX水平显著高于对照组,MDA水平明显低于对照组,差异均有统计学意义(P<0.05或P<0.01)。观察组皮疹发生率低于对照组(P<0.05)。结论知柏地黄口服液联合丙硫氧嘧啶辅治甲亢效果显著,能明显改善患者的临床症状,促进甲状腺功能和血清抗氧化指标恢复正常,并能有效减少不良反应的发生。

Effect of Adjuvant Therapy of Zhibai Dihuang Oral Liquid Combined with Propylthiouracil in the Treatment of Hyperthyroidism and Its Effect on Thyroid Hormones and Antioxidant Indices

Objective To observe the effect of adjuvant therapy of Zhibai Dihuang oral liquid combined with propylthiouracil in the treatment of hyperthyroidism and its effect on thyroid hormones and antioxidant indices. Methods A total of 82 patients with hyperthyroidism who were treated in our hospital from March 2017 to April 2018 were selected. According to different treatment methods, they were divided into observation group and control group, with 41 patients in each group. Control group was given propylthiouracil and propranolol tablets, while observation group was supplemented with Zhibai Dihuang oral liquid. The clinical effects at 12 weeks after treatment, free triiodothyronine(FT3), free thyroxine(FT4) and antioxidant indices [superoxide dismutase(SOD), glutathione peroxidase(GPX), and malondialdehyde(MDA)] before treatment and at 12 weeks after treatment, and the incidence of adverse reactions during treatment were compared between two groups. Results The total effective rate of observation group was 97.56%, which was significantly higher than that of control group(82.93%)(P<0.05).The levels of FT3 and FT4 in two groups were significantly lower than those before treatment. and the degree of reduction in FT3 and FT4 in observation group was significantly greater than that in control group(P<0.05 or P<0.01). After treatment, the levels of SOD and GPX in two groups were significantly higher, while the levels of MDA were significantly lower in both groups, as compared with those before treatment. After treatment, the levels of SOD and GPX in observation group were significantly higher than those in control group, whereas the level of MDA in observation group was significantly lower than that in control group(P<0.05 or P<0.01).The incidence of rash in observation group was significantly lower than that in control group(P<0.05). Conclusion The adjuvant therapy of Zhibai Dihuang oral liquid combined with propylthiouracil has a significant effect in the treatment of hyperthyroidism, which can significantly improve the clinical symptoms of patients, promote the recovery of thyroid function and serum antioxidant indices, and can effectively reduce the incidence of adverse reactions in patients.