| 肝血窦内皮细胞在非酒精性脂肪性肝病发展中的作用 |
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| 引用本文： | 蒋钊,阮柏.肝血窦内皮细胞在非酒精性脂肪性肝病发展中的作用[J].临床肝胆病杂志,2020,36(3):684-686. |
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| 作者姓名： | 蒋钊 阮柏 |
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| 作者单位： | 空军军医大学基础医学院学员一大队,西安710032;空军军医大学航空航天临床医学中心,西安710032;西京医院肝胆胰脾外科,西安710032 |
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| 基金项目： | 国家自然科学基金项目(81800533);陕西省自然科学基础研究计划(2019JQ-015)。 |
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| 摘 要： | 非酒精性脂肪性肝病(NAFLD)是以肝脏脂肪变、炎症和纤维化为主要表现的临床代谢综合征,日渐成为严重影响公众健康的常见慢性肝病。肝血窦内皮细胞(LSEC)是肝脏组织特化的血管内皮细胞,作为一道重要的血管屏障,其对肝脏细胞吸收和代谢源自肠道血液中的营养与物质成分发挥重要调节作用。介绍了NAFLD发生发展进程中LSEC毛细血管化、血管功能障碍及其参与调控肝脏炎症、血管生成、肝纤维化的研究进展。
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| 关 键 词： | 非酒精性脂肪性肝病 毛细血管 内皮细胞 |
The role of liver sinusoidal endothelial cells in the progression of nonalcoholic fatty liver disease |
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| JIANG Zhao,RUAN Bai.The role of liver sinusoidal endothelial cells in the progression of nonalcoholic fatty liver disease[J].Chinese Journal of Clinical Hepatology,2020,36(3):684-686. |
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| Authors: | JIANG Zhao RUAN Bai |
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| Institution: | (st Cadet Regiment,School of Basic Medical Sciences,Air Force Medical University,Xi’an 710032,China) |
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| Abstract: | Nonalcoholic fatty liver disease(NAFLD)is a clinical metabolic syndrome characterized by hepatic steatosis,inflammation,and fibrosis and has become a common chronic liver disease with great impact on public health.Liver sinusoidal endothelial cells(LSECs)are specialized vascular endothelium of liver tissue,and as an important vascular barrier,LSECs play an important role in regulating the absorption and metabolism of nutrients and substances from the blood of the intestines in hepatocytes.This article reviews the research advances in LSEC capillarization,vascular dysfunction,and its involvement in the regulation of liver inflammation,angiogenesis,and liver fibrosis during the development and progression of NAFLD. |
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| Keywords: | non-alcoholic fatty liver disease capillaries endothelial cells |
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