Effect of uric acid-lowering therapy on blood pressure: systematic review and meta-analysis |
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| Authors: | Li-hui Qu Jiang-hua Chen |
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| Affiliation: | 1. Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, P.R. China;2. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, Beijing, P.R. China;3. Key Laboratory of Multiple Organ Transplantation, Ministry of Health, Hangzhou, P.R. China;4. Key Laboratory of Nephropathy, Hangzhou, P.R. China |
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| Abstract: | Background: The purpose of this meta-analysis was to determine if uric acid-lowering therapy is associated with a decrease in blood pressure (BP) and serum creatinine levels.Materials and methods: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until 29 June 2016, with keywords: uric-acid-lowering therapy, allopurinol, febuxostat, uricosuric, and BP. Only randomized controlled trials were included. The primary outcomes were reduction in systolic BP (SBP) and diastolic BP (DBP), and secondary was reduction in serum creatinine level.Results: Patients treated with allopurinol had greater reduction in SBP (standardized difference in means [SDM]?=?0.321, 95% confidence interval [CI]: 0.145–0.497, p?300?mg/day) in patients receiving antihypertensive drugs.Conclusions: These results support that allopurinol decreases BP and creatinine levels in patients with hyperuricemia.- KEY MESSAGES
Allopurinol decreases SBP and DPB, and creatinine levels in patients with hyperuricemia. Allopurinol resulted in a significant decrease in SBP in patients with or without treatment of antihypertensive drugs. A dose of allopurinol of ≤300?mg per day might be more effective than a higher dose.
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| Keywords: | Allopurinol blood pressure gout hypertension meta-analysis renal disease uric acid |
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