|
|||||
|
|
Neuronal nitric oxide synthase polymorphisms in obsessive-compulsive disorder |
|
| Authors: | Muruvvet Topaloglu Erdem Tuzun Huseyin Gulec Elif Sinem Bireller Bedia Cakmakoglu |
| Affiliation: | 1. Department of Neurology, Istanbul Erenkoy Psychiatric and Neurological Disorders Hospital, Istanbul, Turkey;2. Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey;3. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul Yeni Yuzyil University, Istanbul, Turkey;4. Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey |
| Abstract: | Background: Obsessive-compulsive disorder (OCD) is a mental disease characterized by recurrent and intrusive thoughts and repetitive behaviours that negatively affect the quality-of-life of the patients. Recent studies have implicated the participation of neuronal nitric oxide in OCD pathogenesis as a neurotransmitter modulator.Aims: To identify whether variations in neuronal nitric oxide synthase (nNOS) genes may render individuals susceptible to OCD development.Methods: This study examined nNOS polymorphisms in 100 OCD patients and 121 unrelated healthy controls by polymerase chain reaction and restriction enzyme digestion methods.Results: nNOS 276 C?+?genotype incidence was significantly higher in OCD patients than controls and conferred a 2-fold increased risk for OCD. No significant differences were observed in frequencies of nNOS 84 genotypes between patients and controls.Conclusion: This study shows an association between nNOS gene polymorphism and OCD. Exact mechanisms by which nNOS gene variants contribute to OCD pathogenesis need to be further investigated. |
| Keywords: | Obsessive-compulsive disorder neuronal nitric oxide synthase polymorphism |