氯丙嗪与奎硫平对血脂和血糖的影响

目的:研究氯丙嗪与奎硫平对精神分裂症患者血脂与血糖的影响。方法:130例精神分裂症患者随机分为氯丙嗪组(65例)与奎硫平组(65例),治疗8周。所有患者于治疗前与治疗4、8周测空腹血糖、总胆固醇、三酰甘油和体质量(体重)。结果:氯丙嗪组总胆固醇、三酰甘油、体质量在治疗第4、8周均较治疗前显著升高(P<0.01);奎硫平组三酰甘油、体质量在治疗第4、8周均较治疗前显著升高(P<0.01)。治疗8周后,两组男性患者总胆固醇与空腹血糖较治疗前均显著升高(P<0.01),女性患者三酰甘油与总胆固醇治疗后较治疗前显著升高(P<0.01)。结论:氯丙嗪与奎硫平对血脂和血糖的影响不同,2药对血脂与血糖的影响存在性别差异。

The effect of chlorpromazine and quetiapine on serum lipid and glucose

Objective:To study the effect of chlorpromazine and quetiapine on serum lipid and glucose in schizophrenia.Method:130 patients with schizophrenia were divided into chlorpromazine group(n=65)and quetiapine group(n=65)randomly for eight weeks.All the patients were measured fasting blood glucose,cholesterol,triglyceride and body weight before and after treatments for 4,8 weeks.Results:After four-week and eight-week treatment,the concentrations of cholestorol triglyceride and body weight increased significantly in chlorpromazine group(P<0.01).After four-week and eight-week treatment,the concentrations of triglyceride and body weight increased significantly in quetiapine group(P<0.01).After eight-week treatment,the concentrations of cholesterol and glucose increased markedly in male(P<0.01),and the concentrations of triglyceride and cholesterol significantly increased in female(P<0.01).Conclusion:Chlorpromazine and quetiapine differ in their effect on serum lipid and glucose.Gender differences exist in effect of chlorpromazine and quetiapine on serum lipid and glucose.