高原藏族酒精性肝病的临床病理和电镜观察

探讨酒精性肝病（ＡＬＤ）的超微结构特点及其与肝功能损害程度的关系。方法对２０例高原藏族ＡＬＤ患者行肝穿活检组织病理学观察。结果性脂肪肝（ＡＦＬ）、酒精性肝炎（ＡＨ）、酒精性肝硬化（ＡＬＣ）常相继发生或同时存在，主要表现为肝细胞大泡性脂变，窦周纤维化，肝细胞滑面内质网增生，小叶内灶状坏死伴中性粒细胞浸润。

Clinicopathological and Ultrastructural Studies of Alcoholic Liver Diseases in Tibetan Plateau

Objective To investigate the ultastructural characteristics of alcoholic liver disease (ALD) and the relationship between ALD and the degree of liver functional damage. Methods Liver tissues obtained by puncture biopsy were examined in 20 cases of Tibetan ALDs. Results Alcoholic fatty degeneration, alcoholic hepatitis and alcohonic liver cirrhosis always co-existed or occurred consequentially. The main pathologic changes were a focal ballooning fatty degeneration, perisinuous fibrosis and hyperplasia of smooth endoplasmic reticulum of liver cells, and focal necrosis with neutrophilic granulocyte infiltration. No matter what degree of liver damage was liver function was always abnormal, especially more severe in the patient whose A/G ratio was less 1. Conclusion The activation of fat-storing cells will directly effects on the consequence of the liver disease and the degree of liver functional damage. Other factors which involve in ALDs were also discussed.