Uncoupler-accelerated efflux of 5-hydroxytryptamine from platelets of healthy subjects and patients with unipolar and bipolar depression |
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| Authors: | Lou-Lou Peterson Tamas Bartfai Lars Ernster Göran Wickström Björn-Erik Roos Ulla Wehlin-Åhs Hans Ågren |
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| Affiliation: | 1. Lou-Lou Peterson, B.S., Tamas Bartfai, Ph.D., and Lars Ernster, Ph.D., are in the Department of Biochemistry (Head: Professor Lars Ernster), Arrhenius Laboratory, University of Stockholm, Stockholm, Sweden;2. Göran Wickström, M.D., Björn-Erik Roos, M.D., and Ulla Wehlin-Åhs, B.S., are in the Department of Psychiatry (Head Professor Björn-Erik Roos), University Hospital, Uppsala, Sweden;3. Hans Ågren, M.D., is Visiting Scientist, Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD 20205, USA |
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| Abstract: | The efflux of 14C-5-hydroxytryptamine (5HT) from platelets of 25 depressed patients (16 unipolar and 9 bipolar) and 22 control subjects was studied in the presence of carbamyl cyanide m-chlorophenylhydrazone (FCCP), which dissipates H+ gradients. FCCP (0.31 microM), at 10 minutes' incubation time, enhanced the efflux of 14C-5HT to a significantly higher extent from platelets of patients with bipolar depression than from platelets of control subjects. An analysis of variance revealed a significant interaction between the diagnostic categories (unipolar, bipolar, and control) and sex in accounting for variation of the FCCP-evoked efflux. The diagnostic category X sex effect was also significant. The results reported indicate that the FCCP-evoked efflux of 5HT is an easily measured biochemical parameter of possible diagnostic interest. |
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| Keywords: | Unipolar depression bipolar depression platelets 5-hydroxytryptamine efflux uncoupler |
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