重组人胰岛素不同给药方式用于糖尿病酮症酸中毒的对比研究

目的观察重组人胰岛素两种不同给药方式治疗糖尿病酮症酸中毒的临床效果。方法将68例糖尿病酮症酸中毒患者随机分为两组,其中对照组33例采用常规小剂量胰岛素静脉滴注的方式给药,观察组35例采用胰岛素泵持续24h不间断皮下泵入的给药方式,分别观察两组治疗后空腹血糖（FBG）值、pH值恢复时间、血糖达标时间、尿酮体转阴时间、胰岛素平均用量以及人均低血糖发生次数等。结果与对照组比较,经治疗后观察组FBG水平差异无统计学意义（P＞0.05）,但在pH值恢复时间、血糖达标时间、尿酮体转阴时间、胰岛素平均用量及人均低血糖发生次数等方面均明显减少（P〈0.05或〈0.01）。结论胰岛素泵持续不间断皮下泵入的给药方式治疗糖尿病酮症酸中毒能有效、较快地控制血糖水平,且低血糖发生风险低。

Comparison study of different methods of administration of recombinant human insulin for diabetic ketoacidosis

Objective To evaluate the clinical effects of different methods of administration of recombinant human insulin for diabetic ketoacidosis. Methods 68 cases with diabetic ketoacidosis were randomly divided into the control group （33 cases） and the observation group（35 cases）.The control group were treated with conventional low-dose in- sulin by intravenous drip,while the observation group were given insulin by 24 hours of continous subcutaneous pum- ping by means of insulin pump.Then,the value of fasting blood glucose （FBG）, the recovery time of pH, the time of blood glucose up to standard,the time for uricketobody turning negative,average dosages of insulin and the incidence of hypoglycemia per capita,etc.were oBserved.Results There was no statistical significance in the comparison of FBG levels between two groups after treatment （ P 〉0.05）. However, pH recovery time, the time of blood glucose up to Standard,time for uricketobody turning negative, average dosages of insulin and incidence of hypoglycemia per capita all decreased significantly（ P 〈0.05 or 〈0,01）.Conclusion Continous subcutaneous pumping by insulin pump for diabetic ketoacidosis can rapidly and effectively control blood glucose levels with a low incidence of glycopenia.