New World monkey Aotus nancymae as a model for Campylobacter jejuni infection and immunity |
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| Authors: | Jones Franca R Baqar Shahida Gozalo Alfonso Nunez Gladys Espinoza Nereyda Reyes Sharina M Salazar Milagros Meza Rina Porter Chad K Walz Stephen E |
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| Affiliation: | Naval Medical Research Center, Biological Defense Research Directorate, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. jonesf@nmrc.navy.mil |
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| Abstract: | Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy. |
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