| 重症肌无力胸腺摘除前后血清抗乙酰胆碱受体抗体、抗突触前膜抗体及可溶性白细胞介素_2受体的变化 |
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| 引用本文： | 张清勇,魏云,王铁栓,杜英,张斌,王宪忠. 重症肌无力胸腺摘除前后血清抗乙酰胆碱受体抗体、抗突触前膜抗体及可溶性白细胞介素_2受体的变化[J]. 中华实验外科杂志, 1999, 0(3) |
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| 作者姓名： | 张清勇 魏云 王铁栓 杜英 张斌 王宪忠 |
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| 作者单位： | 河南医科大学第二附属医院胸外科!郑州，450003，河南医科大学第二附属医院胸外科!郑州，450003，河南医科大学第二附属医院胸外科!郑州，450003，河南医科大学微生物学与免疫学教研室，河南医科大学第二附属医院胸外科!郑州，450003，河南省永城县人民医院 |
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| 基金项目： | 河南省自然科学基金!964021500 |
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| 摘 要： | 目的探讨胸腺摘除对重症肌无力患者血清抗乙酸胆感受体抗体、抗灾触前膜抗体（AchRab）、（PrM））和可溶性白细胞介素2受体（sIL－2R）水平的影响。方法采取39例重症肌无力（myastheniagravis，MG）患者在胸腺摘除前后和40例健康献血员血清，用ELISA法检出AchRab、PrM及sIL－2R的水平。结果64．2％的重症肌无力患者血清AchRab显著增高，27．5％的重症肌无力患者PsmRab显著增高，AchRab和PrM同时增高者占15％。重症肌无力患者血清sIL-2R显著高于正常者占79.6％。三项指标在胸腺摘除后有显著下降的比例分别为48％、45％、32％。结论胸腺摘除对外周血中的AchRab、PrM、sIL-2R有明显下调作用。
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| 关 键 词： | 重症肌无力 胸腺摘除 AchRab PrM 可溶性白细胞介_2素受体 |
Serum AchRab, PrM and sIL-2R in patients with myasthenia Gravis before and after thymectomy |
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| ZHAN Qingpong, WEI Yun, WANG Tieshuan. Serum AchRab, PrM and sIL-2R in patients with myasthenia Gravis before and after thymectomy[J]. Chinese Journal of Experimental Surgery, 1999, 0(3) |
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| Authors: | ZHAN Qingpong WEI Yun WANG Tieshuan |
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| Abstract: | Objective To investigate the changes in serum AchRab, PrM, sIL-2R in patients withmyasthenia Gravis (MG) before and after thymectomy. Method Serum AchRab. PrM, and sIb-2R in MGpatients were determined with ELISA. Results The positive rate of AchRab and PrM in MG patients was64. 2 % and 27. 5 % respectively. The peitive rate of both AchRab and PrM in MG patients was 15 %. SerumsIL-2R level of 79. 6% MG patients was obviously increased as compared with that of normal subjects. Afterthymectomy, the titers of AchRab, PrM and sIL-2R were markedly decreased with the ratio beng 48%,45% and 32% respectively. Conclusion Thyrnectomy could induce the down-regulation of serum AchRab,PrM and sIL-2R. |
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| Keywords: | Myasthenia Gravis Thyrnectomy AchRab PrM sIL-2R |
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