| Churg-Strauss综合征发病机制研究进展 |
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| 引用本文： | 林进,厉有名. Churg-Strauss综合征发病机制研究进展[J]. 国外医学:内科学分册, 2007, 34(1): 49-51 |
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| 作者姓名： | 林进 厉有名 |
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| 作者单位： | 浙江大学医学院附属第一医院风湿免疫科,浙江,杭州,310003;浙江大学医学院附属第一医院风湿免疫科,浙江,杭州,310003 |
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| 摘 要： | Churg-Strauss综合征(CSS)是一种常伴有哮喘的系统性血管炎.迄今为止,CSS的病因和发病机制仍不甚明了.外周血和组织中嗜酸性粒细胞(EOS)增多及EOS代谢产物水平升高,表明EOS参与CSS发病.此外,T细胞分泌细胞因子和致炎因子大量释放,提示T细胞激活."抗中性粒细胞胞浆抗体(ANCA)-细胞因子-序列理论"认为CSS的发病与ANCA和中性粒细胞也有关.
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| 关 键 词： | Churg-Strauss综合征 嗜酸性粒细胞 T细胞 中性粒细胞 抗中性粒细胞胞浆抗体 |
| 文章编号： | 1004-2369（2007）01-0049-03 |
| 修稿时间： | 2006-04-202006-08-10 |
Update on the pathogenesis of Churg-Strauss Syndrome |
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| LIN Jin,LI You-ming. Update on the pathogenesis of Churg-Strauss Syndrome[J]. Foreign Medical Sciences(Section of Internal Medicine), 2007, 34(1): 49-51 |
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| Authors: | LIN Jin LI You-ming |
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| Affiliation: | Department of Rheumatology and Immunology, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China |
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| Abstract: | Churg-Srauss syndrome(CSS) is a systemic vasculitis occurring in patients with asthma.Up to now,the cause and pathogenesis are still unclear.The presence of a marked tissue-and blood-eosinophilia as well the metabolite from eosinophils,suggests that eosinoplils play an important role in the pathogenesis of CSS.Besides,T 1ymphocytes secrete cytokines and chemokines,suggests T 1ymphocytes are activated in CSS."Antineutrophil cytoplasmic antibody(ANCA)-cytokinessequences-theory"presumes that ANCA and neutrophils could play important roles in pathogenesis of CSS. |
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| Keywords: | Churg-Srauss syndrome Pathogenesis Eosinophils Interlukin-5 T lymphocytes Neutrophils ANCA |
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