Neurotoxicity of organophosphorus pesticides: predictions can be based on in vitro studies with hen and human enzymes |
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| Authors: | Marcello Lotti Martin Keith Johnson |
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| Affiliation: | (1) Molecular Toxicology Section, MRC Toxicology Unit, Woodmansterne Road, SM5 4EF Carshalton, Surrey, Great Britain |
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| Abstract: | The comparative inhibitory power of organophosphorus esters in vitro against hen brain acetylcholinesterase and neurotoxic esterase correlates with their comparative effects (death or delayed neuropathy) in vivo. Further comparisons of the in vitro effects seen with hen and human enzymes facilitates extrapolations to the human in vivo situation.Visiting worker from Istituto di Medicina del Lavoro. Universita di Padova (Italy) |
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| Keywords: | Neuropathy Organophosphorus Prediction of neurotoxicity In vitro tests |
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