社区糖尿病患者痴呆患病率调查

目的 调查社区糖尿病患者痴呆患病率,计算年龄别、性别患病率,并与非糖尿病组相比较.方法 对上海市某社区50岁以上常住居民中糖尿病患者及与其年龄、性别相匹配1:1对照的非糖尿病患者进行调查.运用问卷采集人口学及病史资料,MMSE筛查认知功能.对于文盲≤19分、小学≤21分、初中及以上文化程度≤24分者,进一步给予成套神经心理学量表检查,依据DSM-Ⅳ诊断痴呆.结果 糖尿病患者中痴呆患病率[4.75%(23/484),95%CI:3.03%～7.04%]高于非糖尿病患者[2.24%(11/490),95%CI:1.13%～3.98% X~2=4.54,P=0.03].糖尿病组60～69、70～79和80岁以上各年龄段的痴呆患病率分别为1.94%(2/103)、4.43%(9/203)和14.12%(12/85)(趋势X~2=18.04,P<0.01);非糖尿病组相应年龄段痴呆患病率分别为1.43%(2/140)、2.86%(6/210)和5.00%(3/60,趋势X~2=4.58,P:0.03).糖尿病组女性和男性痴呆患病率分别为6.55%(19/290)和2.06%(4/194,X~2=5.18,P=0.02);非糖尿病组女性和男性痴呆患病率分别为3.01%(9/299)和1.05%(2/191).结论 糖尿病患者中痴呆患病率显著高于非糖尿病患者,2组痴呆患病率均随年龄增大而升高,并且女性痴呆患病率高于男性.

Prevalence of dementia in diabetics: a community-based case-control study

Objective To determine prevalence of dementia in diabetics and non-diabetics, and in different age and gender groups. Methods A case-control study was conducted among participants aged 50 and over in Jing' an temple community in Shanghai. Subjects in diabetics group were matched to non-diabetics groups for age and sex with 1:1 matching. Personal information and case history were collected through questionnaire. The subjects were screened for dementia using the Mini Mental State Examination (MMSE). Subjects that screened positively (indicated by an MMSE score below 19, 21 and 24 among those with illiteracy, elementary school and above junior middle school education, respectively) were subsequently examined by a series of neuropsychological tests. Based on all available information, a diagnosis of dementia was defined according to the Diagnostic and Statistical Manual of Mental Disorders ( DSM )-Ⅳ criteria Results Prevalence of dementia of 4. 75% (23/484, 95% CI: 3. 03%-7.04%) in diabetics was higher than that of 2. 24% (11/490,95% CI: 1.13% -3.98%) in non-diabetics (X~2 = 4.54, P=0.03).Prevalence of dementia among diabetics in age groups of 60-69, 70-79 and 80 and above was 1.94% (2/103), 4. 43 % (9/203) and 14.12% (12/85, trend X~2 =18.04, P <0.01), and in non-diabetics was 1.43% (2/140), 2. 86% (6/210) and 5.00% (3/60, trend X~2 = 4.58, P=0.03), respectively.Prevalence of dementia among female and male in diabetics was 6.55% (19/299) and 2.06% (4/194) (X~2 = 5.18, P = 0.02), respectively, and in non-diabetics was 3.01% (9/299) and 1.05% (2/191).Conclusions Prevalence of dementia is significantly higher in diabetics than in non-diabetics, higher in women than men, and increases as age rises.