Positive Expression of L1-CAM is Associated with Perineural Invasion and Poor Outcome in Pancreatic Ductal Adenocarcinoma |
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| Authors: | Qi-Wen Ben Jian-Cheng Wang Jun Liu Ying Zhu Fei Yuan Wei-Yan Yao Yao-Zong Yuan |
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| Affiliation: | (1) Department of Gastroenterology, School of Medicine, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, People’s Republic of China;(2) Department of Surgery, School of Medicine, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, People’s Republic of China;(3) Department of Pathology, School of Medicine, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, People’s Republic of China; |
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| Abstract: | Background Pancreatic ductal adenocarcinoma (PDAC) frequently invades and migrates along neural tissue, which results in local tumor recurrences, distant metastases, and poor prognosis. We evaluated whether L1 cell adhesion molecule (L1-CAM) and glial cell line-derived neurotrophic factor (GDNF) expression in PDAC correlated with neural invasion and overall survival on a large cohort of previously untreated patients. |
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