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| 高球蛋白血症性紫癜并发原发性干燥综合征一例 | |
| 引用本文： | 杨丹丹,张杰. 高球蛋白血症性紫癜并发原发性干燥综合征一例[J]. 中国麻风皮肤病杂志, 2019, 35(2): 92-95. DOI: 10.12144/zgmfskin201902092 |
| 作者姓名： | 杨丹丹 张杰 |
| 作者单位： | 1中国医科大学附属第一医院， 辽宁沈阳,1100012辽宁中医药大学,辽宁沈阳,110847 |
| 基金项目： | 辽宁省中医药学(专)科能力建设项目(辽卫函[编号:2018]27号);辽宁省名老中医工作室建设项目(辽卫函[编号:2016]78号);国家重点基础研究发展计划分课题(973计划)项目(编号:2013CB531704) |
| 摘 要： | 患者,女,47岁。双下肢反复出现瘀点、瘀斑4个月,劳累、不良情绪刺激后加重。实验室检查球蛋白增高、血沉增快、类风湿因子强阳性、轻度贫血、血小板正常;抗SSA、SSB抗体2+,Schirmer试验+,唾液腺ECT:唾液腺自主排泌功能降低。唇腺病理活检符合干燥综合征。结合患者临床表现,诊断为高球蛋白血症性紫癜合并原发性干燥综合征。使用糖皮质激素联合羟氯喹、乙酰半胱氨酸、白芍总苷等口服并规律减量,随访2年病情稳定无复发。 |
| 关 键 词： | 高球蛋白血症性紫癜 干燥综合征 |
Primary sjogren's syndrome complicated with hyperglobulinemic purpura: a case report |
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| YANG Dandan,ZHANG Jie. Primary sjogren's syndrome complicated with hyperglobulinemic purpura: a case report[J]. China Journal of Leprosy and Skin Diseases, 2019, 35(2): 92-95. DOI: 10.12144/zgmfskin201902092 | |
| Authors: | YANG Dandan ZHANG Jie |
| Affiliation: | 1. The First Affiliated Hospital of China Medical University, Shenyang 110001，China; 2. Liaoning University of Traditional Chinese Medicine, Shenyang 110847，China |
| Abstract: | A 47-year-old female presented with leg petechiae and ecchymosis for 4 months. The symptoms were aggravated after fatigue and bad mood stimulation. Laboratory examination showed an increase in globulin levels and erythrocyte sedimentation rate, strong positivity of rheumoid factor, mild anemia, but normality of platelet counting. SSA/SSB and Schirmer test were positive. The function of salivary glands was decreased. The features of biopsy was in accordance with the diagnosis of sjogren's syndrome. The diagnosis of hyperglobulinemic purpura complicated with Sjogren syndrome was made. There was no recurrence of skin lesions after combined therapy with glucocorticoid, gydroxychloroquine, N-acetylcysteine and paeony during 2 years follow-up. |
| Keywords: | hyperglobulinemia purpura sjogren's syndrome |
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