血清IL-17和IL-23水平与梅毒病期的相关性

目的:明确梅毒病期与IL-17和IL-23表达的相关性。方法:采用ELISA法检测收集到的早期梅毒和晚期梅毒患者血清中的IL-17和IL-23水平。结果:共检测18例早期梅毒,18例晚期梅毒及12例正常对照血清。早期梅毒组和晚期梅毒组IL-17分别为(12.723±8.547)ng/L和(18.757±10.607)ng/L,差异无统计学意义(P>0.05);IL-23水平分别为(9.049±7.301)ng/L和(13.603±7.694)ng/L,差异无统计学意义(P>0.05)。早、晚期梅毒患者IL-17和IL-23水平均高于对照组患者(5.766±2.153)ng/L和(2.756±1.843)ng/L](均P<0.05)。结论:梅毒患者血清中的IL-17和IL-23表达水平与病期无相关性。

The relationship of the levels of IL-17 and IL-23 in serum with syphilis

Objective: To study the correlation between the level of IL-17 and IL-23 and the different courses of syphilis. Methods: The serum levels of IL-17 and IL-23 in the patients with early syphilis and late syphilis were detected by ELISA. Results: The sera of eighteen patients with early syphilis, 18 patients with late syphilis and 12 healthy controls were collected. The level of IL-17 in the patients with early syphilis and patients with late syphilis were (12.723±8.547)ng/L, (18.757±10.607)ng/L, respectively, with no significant difference (P>0.05)；The level of IL-23 were (9.049±7.301) ng/L, (13.603±7.694)ng/L, respectively, with no significant difference (P>0.05). The level of IL-17 and IL-23 in the early syphilis patients and late syphilis patients were higher than those in healthy controls ［(5.766±2.153)ng/L, (2.756±1.843)ng/L, respectively］ (Ps<0.05). Conclusion: There is no correlation between the level of IL-17 and IL-23 and the courses of TP syphilis.